Εξειδίκευση τύπου :	Άρθρο σε επιστημονικό περιοδικό
Τίτλος:	Potential Health Benefits of Banana Phenolic Content during Ripening by Implementing Analytical and In Silico Techniques
Δημιουργός/Συγγραφέας:	Kritsi, Eftichia Tsiaka, Thalia [EL] Σωτηρούδης, Γιώργος[EN] Sotiroudis, Georgios Mouka, Elizabeth Aouant, Konstantinos Ladika, Georgia Zoumpoulakis, Panagiotis Cavouras, Dionisis Sinanoglou, Vassilia J
Ημερομηνία:	2023-01-25
Γλώσσα:	Αγγλικά
ISSN:	2075-1729
DOI:	10.3390/life13020332
Άλλο:	36836689
Περίληψη:	Banana ranks as the fifth most cultivated agricultural crop globally, highlighting its crucial socio-economic role. The banana's health-promoting benefits are correlated with its composition in bioactive compounds, such as phenolic compounds. Thus, the present study attempts to evaluate the potential health benefits of banana phenolic content by combing analytical and in silico techniques. Particularly, the total phenolic content and antioxidant/antiradical activity of banana samples during ripening were determined spectrophotometrically. In parallel, liquid chromatography-tandem mass spectrometry (LC-MS/MS) analysis was implemented to unravel the variations in the phenolic profile of banana samples during ripening. Chlorogenic acid emerged as a ripening marker of banana, while apigenin and naringenin were abundant in the unripe fruit. In a further step, the binding potential of the elucidated phytochemicals was examined by utilizing molecular target prediction tools. Human carbonic anhydrase II (hCA-II) and XII (hCA-XII) enzymes were identified as the most promising targets and the inhibitory affinity of phenolic compounds was predicted through molecular docking studies. This class of enzymes is linked to a variety of pathological conditions, such as edema, obesity, hypertension, cancer, etc. The results assessment indicated that all assigned phenolic compounds constitute great candidates with potential inhibitory activity against CA enzymes.
Τίτλος πηγής δημοσίευσης:	Life (Basel, Switzerland)
Τόμος/Κεφάλαιο:	13
Τεύχος:	2
Θεματική Κατηγορία:	[EL] Αναλυτική χημεία[EN] Analytical chemistry [EL] Φασματοσκοπία[EN] Spectroscopy [EL] Βοτανική χημεία. Φυτοχημικά[EN] Botanical chemistry. Phytochemicals [EL] Δομική Βιολογία[EN] Structural Biology
Λέξεις-Κλειδιά:	Antioxidant and antiradical capacity Banana fruit Carbonic anhydrase enzymes in silico tools Liquid chromatography-mass spectrometry (LC-MS/MS) Phenolic compounds Potential health benefits ripening
Κάτοχος πνευματικών δικαιωμάτων:	© 2023 by the authors. Licensee MDPI, Basel, Switzerland.
Όροι και προϋποθέσεις δικαιωμάτων:	This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https:// creativecommons.org/licenses/by/ 4.0/).
Ηλεκτρονική διεύθυνση στον εκδότη (link):	https://www.mdpi.com/2075-1729/13/2/332
Εμφανίζεται στις συλλογές:	Ινστιτούτο Χημικής Βιολογίας - Επιστημονικό έργο