Εξειδίκευση τύπου :	Κεφάλαιο βιβλίου
Τίτλος:	Lipoplexes and Polyplexes for Targeted Gene Delivery
Δημιουργός/Συγγραφέας:	Kafetzi, Martha Pippa, Natassa Selianitis, Dimitrios [EL] Πίσπας, Στέργιος[EN] Pispas, Stergios Gazouli, Maria
Ημερομηνία:	2022-10
Γλώσσα:	Αγγλικά
ISBN:	978-3-031-12657-4 978-3-031-12658-1
ISSN:	2523-8027 2523-8035
DOI:	10.1007/978-3-031-12658-1_3
Περίληψη:	Targeted gene delivery is a scientific approach with numerous advantages in the fields of bio- and personalized medicine. The delivery of genes and generally nucleic acids (i.e., DNA, RNA, etc.) into cellular and subcellular organelles for the treatment of several diseases seems to be the future in the design and development of medicines with limited adverse drug reactions and a high ratio of effectiveness and efficacy. The increased impact of the targeted gene delivery is in line with the increased usage of the nanosystems and their applications in the development of gene delivery systems. Lipoplexes and polyplexes are the most important nanosystems that are used for targeted gene delivery. They are composed of lipids (cationic and helper lipids) and polymers (cationic and/or stimuli-responsive polymers), respectively. These cationic materials can self-assemble into complexes in the presence of nucleic acids, which are negatively charged. They are also characterized as nonviral (synthetic) carriers of nucleic acids. This chapter aims to present the technology and the applications of lipoplexes and polyplexes in the field of targeted gene delivery. Special attention will be given to the mechanisms by that lipoplexes and polyplexes are utilized for the delivery and release of the complexed nucleic acids.
Σελίδες:	65-92
Σειρά δημοσίευσης:	Pharmaceutical Nanobiotechnology for Targeted Therapy
Θεματική Κατηγορία:	[EL] Βιολογία (Γενικά)[EN] Biology (General) [EL] Χημική Βιολογία[EN] Chemical Biology
Λέξεις-Κλειδιά:	Lipoplexes Polyplexes Nucleic acids Proteins Targeting Gene delivery
Κάτοχος πνευματικών δικαιωμάτων:	© 2022 by the authors
Ηλεκτρονική διεύθυνση στον εκδότη (link):	https://link.springer.com/chapter/10.1007/978-3-031-12658-1_3
Εμφανίζεται στις συλλογές:	Ινστιτούτο Θεωρητικής και Φυσικής Χημείας (ΙΘΦΧ) - Επιστημονικό έργο