Εξειδίκευση τύπου :	Άρθρο σε επιστημονικό περιοδικό
Τίτλος:	A GATA2-CDC6 axis modulates androgen receptor blockade-induced senescence in prostate cancer
Δημιουργός/Συγγραφέας:	Mourkioti, Ioanna Polyzou, Aikaterini Veroutis, Dimitris Theocharous, George Lagopati, Nefeli Gentile, Emanuela Stravokefalou, Vasiliki Thanos, Dimitris-Foivos Havaki, Sophia Kletsas, Dimitris Panaretakis, Theocharis Logothetis, Christopher J [EL] Στέλλας, Δημήτρης[EN] Stellas, Dimitris Petty, Russell Blandino, Giovanni Papaspyropoulos, Angelos Gorgoulis, Vassilis G
Ημερομηνία:	2023-07-29
Γλώσσα:	Αγγλικά
ISSN:	1756-9966
DOI:	10.1186/s13046-023-02769-z
Άλλο:	37507762
Περίληψη:	Prostate cancer is a major cause of cancer morbidity and mortality in men worldwide. Androgen deprivation therapy (ADT) has proven effective in early-stage androgen-sensitive disease, but prostate cancer gradually develops into an androgen-resistant metastatic state in the vast majority of patients. According to our oncogene-induced model for cancer development, senescence is a major tumor progression barrier. However, whether senescence is implicated in the progression of early-stage androgen-sensitive to highly aggressive castration-resistant prostate cancer (CRPC) remains poorly addressed.
Τίτλος πηγής δημοσίευσης:	Journal of experimental & clinical cancer research : CR
Τόμος/Κεφάλαιο:	42
Τεύχος:	1
Θεματική Κατηγορία:	[EL] Νεοπλάσματα. Όγκοι. Ογκολογία (περ. Καρκίνος, κακινογόνες ουσίες)[EN] Neoplasms. Tumors. Oncology (Incl.cancer, carcinogens) [EL] Βιοχημεία[EN] Biochemistry [EL] Χημική Βιολογία[EN] Chemical Biology [EL] Ανοσολογία[EN] Immunology
Λέξεις-Κλειδιά:	AR signaling blockade Cellular senescence Enzalutamide GATA2-CDC6 axis Prostate cancer
EU Grant identifier:	3782, 775 70/3/8916 2020SE01300001 775 (Hippo) 3782 (PACOREL)
Κάτοχος πνευματικών δικαιωμάτων:	© 2023 The Author(s)
Όροι και προϋποθέσεις δικαιωμάτων:	This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativeco mmons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
Ηλεκτρονική διεύθυνση περιοδικού (link) :	https://jeccr.biomedcentral.com/articles/10.1186/s13046-023-02769-z#Fun
Εμφανίζεται στις συλλογές:	Ινστιτούτο Χημικής Βιολογίας - Επιστημονικό έργο