Εξειδίκευση τύπου :	Άρθρο σε επιστημονικό περιοδικό
Τίτλος:	Uncovering the Relationship between Selenium Status, Age, Health, and Dietary Habits: Insights from a Large Population Study including Nonagenarian Offspring from the MARK-AGE Project
Δημιουργός/Συγγραφέας:	Giacconi, Robertina Piacenza, Francesco Aversano, Valentina Zampieri, Michele Bürkle, Alexander Villanueva, María Moreno Dollé, Martijn E T Jansen, Eugène Grune, Tilman [EL] Γκόνος, Ευστάθιος[EN] Gonos, Efstathios S. Franceschi, Claudio Capri, Miriam Weinberger, Birgit Sikora, Ewa Toussaint, Olivier Debacq-Chainiaux, Florence Stuetz, Wolfgang Slagboom, Pieternella Eline Bernhardt, Jürgen Fernández-Sánchez, Maria Luisa Provinciali, Mauro Malavolta, Marco
Εκδότης:	Νutrients
Ημερομηνία:	2023-05-04
Γλώσσα:	Αγγλικά
ISSN:	2072-6643
DOI:	10.3390/nu15092182
Άλλο:	37432362
Περίληψη:	An inadequate selenium (Se) status can accelerate the aging process, increasing the vulnerability to age-related diseases. The study aimed to investigate plasma Se and Se species in a large population, including 2200 older adults from the general population (RASIG), 514 nonagenarian offspring (GO), and 293 GO Spouses (SGO). Plasma Se levels in women exhibit an inverted U-shaped pattern, increasing with age until the post-menopausal period and then declining. Conversely, men exhibit a linear decline in plasma Se levels with age. Subjects from Finland had the highest plasma Se values, while those from Poland had the lowest ones. Plasma Se was influenced by fish and vitamin consumption, but there were no significant differences between RASIG, GO, and SGO. Plasma Se was positively associated with albumin, HDL, total cholesterol, fibrinogen, and triglycerides and negatively associated with homocysteine. Fractionation analysis showed that Se distribution among plasma selenoproteins is affected by age, glucometabolic and inflammatory factors, and being GO or SGO. These findings show that sex-specific, nutritional, and inflammatory factors play a crucial role in the regulation of Se plasma levels throughout the aging process and that the shared environment of GO and SGO plays a role in their distinctive Se fractionation.
Τίτλος πηγής δημοσίευσης:	Nutrients
Τόμος/Κεφάλαιο:	15
Τεύχος:	9
Σελίδες:	13
Θεματική Κατηγορία:	[EL] Βιοχημεία[EN] Biochemistry [EL] Χημική Βιολογία[EN] Chemical Biology [EL] Επιδημίες. Επιδημιολογία[EN] Epidemics. Epidemiology [EL] Δημόσια υγεία. Υγιεινή. Προληπτική ιατρική[EN] Public health. Hygiene. Preventive medicine
Λέξεις-Κλειδιά:	aging inflammation longevity plasma selenium selenium fractionation Female Humans Animals Male Nonagenarians Vitamins Problem Solving Feeding Behavior Selenium
Ηλεκτρονική διεύθυνση στον εκδότη (link):	https://www.mdpi.com/2072-6643/15/9/2182
Σημειώσεις:	This article belongs to the Special Issue Trace Elements and Minerals in Aging and Age-Related Diseases
Εμφανίζεται στις συλλογές:	Ινστιτούτο Χημικής Βιολογίας - Επιστημονικό έργο