Εξειδίκευση τύπου :	Άρθρο σε επιστημονικό περιοδικό
Τίτλος:	Valorizing Constituents of Cashew Nut Shell Liquid toward the Sustainable Development of New Drugs against Chagas Disease
Δημιουργός/Συγγραφέας:	Nunes Lemes, Laís Flávia [EL] Μαγουλάς, Γιώργος[EN] Magoulas, George Souza de Oliveira, Andressa Barrias, Emile de Camargo Nascente, Luciana Granado, Renato Teixeira de Macedo Silva, Sara Ασημομύτης, Ν. de Souza, Wanderley Bolognesi, Maria Laura Romeiro, Luiz Antonio Soares [EL] Καλογεροπούλου, Θεοδώρα[EN] Calogeropoulou, Theodora
Εκδότης:	ACS Publications
Ημερομηνία:	2023-06-12
Γλώσσα:	Αγγλικά
ISSN:	2373-8227 2373-8227
DOI:	10.1021/acsinfecdis.3c00076
Άλλο:	37307287
Περίληψη:	Six new ether phospholipid analogues encompassing constituents from cashew nut shell liquid as the lipid portion were synthesized in an effort to valorize byproducts of the cashew industry toward the generation of potent compounds against Chagas disease. Anacardic acids, cardanols, and cardols were used as the lipid portions and choline as the polar headgroup. The compounds were evaluated for their in vitro antiparasitic activity against different developmental stages of Trypanosoma cruzi. Compounds 16 and 17 were found to be the most potent against T. cruzi epimastigotes, trypomastigotes, and intracellular amastigotes exhibiting selectivity indices against the latter 32-fold and 7-fold higher than current drug benznidazole, respectively. Hence, four out of six analogues can be considered as hit-compounds toward the sustainable development of new treatments for Chagas disease, based on inexpensive agro-waste material.
Τίτλος πηγής δημοσίευσης:	ACS infectious diseases
Τόμος/Κεφάλαιο:	9
Τεύχος:	7
Σελίδες:	13
Θεματική Κατηγορία:	[EL] Φαρμακευτική χημεία[EN] Pharmaceutical chemistry [EL] Χημική Βιολογία[EN] Chemical Biology [EL] Μικροβιολογία[EN] Microbiology [EL] Ιατρική-Δημόσια υγεία[EN] Medicine - public aspects [EL] Οργανική χημεία[EN] Organic chemistry
Λέξεις-Κλειδιά:	Trypanosoma cruzi antiparasitic activity cashew nut shell liquid ether phospholipids ultrastructural studies Sustainable Development Nuts Lipids Anacardium Trypanocidal Agents Chagas Disease
Ηλεκτρονική διεύθυνση στον εκδότη (link):	https://doi.org/10.1021/acsinfecdis.3c00076
Εμφανίζεται στις συλλογές:	Ινστιτούτο Χημικής Βιολογίας - Επιστημονικό έργο