Εξειδίκευση τύπου :	Άρθρο σε επιστημονικό περιοδικό
Τίτλος:	Towards non-invasive monitoring of non-melanoma skin cancer using spatially offset Raman spectroscopy
Δημιουργός/Συγγραφέας:	Vardaki, Martha Z Pavlou, Eleftherios Simantiris, Nikolaos Lampri, Evangeli Seretis, Konstantinos Kourkoumelis, Nikolaos
Εκδότης:	Royal Society of Chemistry
Ημερομηνία:	2023-09-11
Γλώσσα:	Αγγλικά
DOI:	10.1039/d3an00684k
Άλλο:	37593769
Περίληψη:	BCC (basal cell carcinoma) and SCC (squamous cell carcinoma) account for the vast majority of cases of non-melanoma skin cancer (NMSC). The gold standard for the diagnosis remains biopsy, which, however, is an invasive and time-consuming procedure. In this study, we employed spatially offset Raman spectroscopy (SORS), a non-invasive approach, allowing the assessment of deeper skin tissue levels and collection of Raman photons with a bias towards the different layers of epidermis, where the non-melanoma cancers are initially formed and expand. Ex vivo Raman measurements were acquired from 22 skin biopsies using conventional back-scattering and a defocused modality (with and without a spatial offset). The spectral data were assessed against corresponding histopathological data to determine potential prognostic factors for lesion detection. The results revealed a positive correlation of protein and lipid content with the SCC and BCC types, respectively. By further correlating with patient data, multiple factor analysis (MFA) demonstrated a strong clustering of variables based on sex and age in all modalities. Specifically for the defocused modality (zero and 2 mm offset), further clustering occurred based on pathology. This study demonstrates the utility of the SORS technology in NMSC diagnosis prior to histopathological examination on the same tissue.
Τίτλος πηγής δημοσίευσης:	The Analyst
Τόμος/Κεφάλαιο:	148
Τεύχος:	18
Σελίδες:	10
Θεματική Κατηγορία:	[EL] Φασματοσκοπία[EN] Spectroscopy [EL] Νεοπλάσματα. Όγκοι. Ογκολογία (περ. Καρκίνος, κακινογόνες ουσίες)[EN] Neoplasms. Tumors. Oncology (Incl.cancer, carcinogens) [EL] Παθολογία[EN] Pathology
Λέξεις-Κλειδιά:	Humans Spectrum Analysis, Raman Skin Biopsy Skin Neoplasms Carcinoma, Squamous Cell
Ηλεκτρονική διεύθυνση στον εκδότη (link):	https://pubs.rsc.org/en/content/articlelanding/2023/AN/D3AN00684K
Εμφανίζεται στις συλλογές:	Ινστιτούτο Χημικής Βιολογίας - Επιστημονικό έργο