Εξειδίκευση τύπου :	Άρθρο σε επιστημονικό περιοδικό
Τίτλος:	Neuron-specific proteasome activation exerts cell non-autonomous protection against amyloid-beta (Aβ) proteotoxicity in Caenorhabditis elegans
Δημιουργός/Συγγραφέας:	Panagiotidou, Eleni Gioran, Anna Bano, Daniele [EL] Χονδρογιάννη, Νίκη[EN] Chondrogianni, Niki
Ημερομηνία:	2023-07-13
Γλώσσα:	Αγγλικά
ISSN:	22132317
DOI:	10.1016/j.redox.2023.102817
Άλλο:	37473700
Περίληψη:	Proteostasis reinforcement is a promising approach in the design of therapeutic interventions against proteinopathies, including Alzheimer's disease. Understanding how and which parts of the proteostasis network should be enhanced is crucial in developing efficient therapeutic strategies. The ability of specific tissues to induce proteostatic responses in distal ones (cell non-autonomous regulation of proteostasis) is attracting interest. Although the proteasome is a major protein degradation node, nothing is known on its cell non-autonomous regulation. We show that proteasome activation in the nervous system can enhance the proteasome activity in the muscle of Caenorhabditis elegans. Mechanistically, this communication depends on Small Clear Vesicles, with glutamate as one of the neurotransmitters required for the distal regulation. More importantly, we demonstrate that this cell non-autonomous proteasome activation is translated into efficient prevention of amyloid-beta (Αβ)-mediated proteotoxic effects in the muscle of C. elegans but notably not to resistance against oxidative stress. Our in vivo data establish a mechanistic link between neuronal proteasome reinforcement and decreased Aβ proteotoxicity in the muscle. The identified distal communication may have serious implications in the design of therapeutic strategies based on tissue-specific proteasome manipulation.
Τίτλος πηγής δημοσίευσης:	Redox biology
Τόμος/Κεφάλαιο:	65
Σελίδες:	17
Θεματική Κατηγορία:	[EL] Βιοχημεία[EN] Biochemistry [EL] Χημική Βιολογία[EN] Chemical Biology
Λέξεις-Κλειδιά:	C. elegans Cell non-autonomous regulation Proteasome Proteinopathies Proteostasis Animals Proteasome Endopeptidase Complex Amyloid beta-Peptides Neurons Caenorhabditis elegans Caenorhabditis elegans Proteins
Ηλεκτρονική διεύθυνση στον εκδότη (link):	https://www.sciencedirect.com/science/article/pii/S2213231723002185?via%3Dihub
Εμφανίζεται στις συλλογές:	Ινστιτούτο Χημικής Βιολογίας - Επιστημονικό έργο