Εξειδίκευση τύπου :	Άρθρο σε επιστημονικό περιοδικό
Τίτλος:	Associations of circulating GDF15 with combined cognitive frailty and depression in older adults of the MARK-AGE study
Δημιουργός/Συγγραφέας:	Kochlik, Bastian Herpich, Catrin Moreno-Villanueva, María Klaus, Susanne Müller-Werdan, Ursula Weinberger, Birgit Fiegl, Simone Toussaint, Olivier Debacq-Chainiaux, Florence Schön, Christiane Bernhard, Jürgen Breusing, Nicolle [EL] Γκόνος, Ευστάθιος[EN] Gonos, Efstathios S. Franceschi, Claudio Capri, Miriam Sikora, Ewa Hervonen, Antti Hurme, Mikko Slagboom, P Eline Dollé, Martijn E T Jansen, Eugene Grune, Tilman Bürkle, Alexander Norman, Kristina
Εκδότης:	Springer
Ημερομηνία:	2023-09-16
Γλώσσα:	Αγγλικά
ISSN:	2509-2723
DOI:	10.1007/s11357-023-00902-6
Άλλο:	37715843
Περίληψη:	Growth differentiation factor-15 (GDF15) might be involved in the development of cognitive frailty and depression. Therefore, we evaluated cross-sectional associations of plasma GDF15 with combined cognitive-frailty-and-depression in older (i.e. ≥ 55 years) and younger adults of the MARK-AGE study. In the present work, samples and data of MARK-AGE ("European study to establish bioMARKers of human AGEing") participants (N = 2736) were analyzed. Cognitive frailty was determined by the global cognitive functioning score (GCF) and depression by the Self-Rating Depression Scale (SDS score). Adults were classified into three groups: (I) neither-cognitive-frailty-nor-depression, (II) either-cognitive-frailty-or-depression or (III) both-cognitive-frailty-and-depression. Cross-sectional associations were determined by unadjusted and by age, BMI, sex, comorbidities and hsCRP-adjusted linear and logistic regression analyses. Cognitive frailty, depression, age and GDF15 were significantly related within the whole study sample. High GDF15 levels were significantly associated with both-cognitive-frailty-and-depression (adjusted β = 0.177 [0.044 - 0.310], p = 0.009), and with low GCF scores and high SDS scores. High GDF15 concentrations and quartiles were significantly associated with higher odds to have both-cognitive-frailty-and-depression (adjusted odds ratio = 2.353 [1.267 - 4.372], p = 0.007; and adjusted odds ratio = 1.414 [1.025 - 1.951], p = 0.035, respectively) independent of age, BMI, sex, comorbidities and hsCRP. These associations remained significant when evaluating older adults. We conclude that plasma GDF15 concentrations are significantly associated with combined cognitive-frailty-and-depression status and, with cognitive frailty and depressive symptoms separately in old as well as young community-dwelling adults.
Τίτλος πηγής δημοσίευσης:	GeroScience
Τόμος/Κεφάλαιο:	45
Τεύχος:	2
Θεματική Κατηγορία:	[EL] Βιοχημεία[EN] Biochemistry [EL] Γηριατρική[EN] Geriatrics [EL] Επιδημίες. Επιδημιολογία[EN] Epidemics. Epidemiology
Λέξεις-Κλειδιά:	Aging Biomarker Cognitive frailty Depression GDF15
EU Grant:	European Study to Establish Biomarkers of Human Ageing f4f— food for the future
EU Grant identifier:	200880 491394008 031B0731E
Κάτοχος πνευματικών δικαιωμάτων:	© 2023. The Author(s)
Ηλεκτρονική διεύθυνση στον εκδότη (link):	https://doi.org/10.1007/s11357-023-00902-6
Σημειώσεις:	The online version contains supplementary material available at https://doi.org/10.1007/s11357-023-00902-6.
Εμφανίζεται στις συλλογές:	Ινστιτούτο Χημικής Βιολογίας - Επιστημονικό έργο