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Εξειδίκευση τύπου : Άρθρο σε επιστημονικό περιοδικό
Τίτλος: Associations of circulating GDF15 with combined cognitive frailty and depression in older adults of the MARK-AGE study
Δημιουργός/Συγγραφέας: Kochlik, Bastian
Herpich, Catrin
Moreno-Villanueva, María
Klaus, Susanne
Müller-Werdan, Ursula
Weinberger, Birgit
Fiegl, Simone
Toussaint, Olivier
Debacq-Chainiaux, Florence
Schön, Christiane
Bernhard, Jürgen
Breusing, Nicolle
[EL] Γκόνος, Ευστάθιος[EN] Gonos, Efstathios S.semantics logo
Franceschi, Claudio
Capri, Miriam
Sikora, Ewa
Hervonen, Antti
Hurme, Mikko
Slagboom, P Eline
Dollé, Martijn E T
Jansen, Eugene
Grune, Tilman
Bürkle, Alexander
Norman, Kristina
Εκδότης: Springer
Ημερομηνία: 2023-09-16
Γλώσσα: Αγγλικά
ISSN: 2509-2723
DOI: 10.1007/s11357-023-00902-6
Άλλο: 37715843
Περίληψη: Growth differentiation factor-15 (GDF15) might be involved in the development of cognitive frailty and depression. Therefore, we evaluated cross-sectional associations of plasma GDF15 with combined cognitive-frailty-and-depression in older (i.e. ≥ 55 years) and younger adults of the MARK-AGE study. In the present work, samples and data of MARK-AGE ("European study to establish bioMARKers of human AGEing") participants (N = 2736) were analyzed. Cognitive frailty was determined by the global cognitive functioning score (GCF) and depression by the Self-Rating Depression Scale (SDS score). Adults were classified into three groups: (I) neither-cognitive-frailty-nor-depression, (II) either-cognitive-frailty-or-depression or (III) both-cognitive-frailty-and-depression. Cross-sectional associations were determined by unadjusted and by age, BMI, sex, comorbidities and hsCRP-adjusted linear and logistic regression analyses. Cognitive frailty, depression, age and GDF15 were significantly related within the whole study sample. High GDF15 levels were significantly associated with both-cognitive-frailty-and-depression (adjusted β = 0.177 [0.044 - 0.310], p = 0.009), and with low GCF scores and high SDS scores. High GDF15 concentrations and quartiles were significantly associated with higher odds to have both-cognitive-frailty-and-depression (adjusted odds ratio = 2.353 [1.267 - 4.372], p = 0.007; and adjusted odds ratio = 1.414 [1.025 - 1.951], p = 0.035, respectively) independent of age, BMI, sex, comorbidities and hsCRP. These associations remained significant when evaluating older adults. We conclude that plasma GDF15 concentrations are significantly associated with combined cognitive-frailty-and-depression status and, with cognitive frailty and depressive symptoms separately in old as well as young community-dwelling adults.
Τίτλος πηγής δημοσίευσης: GeroScience
Τόμος/Κεφάλαιο: 45
Τεύχος: 2
Θεματική Κατηγορία: [EL] Βιοχημεία[EN] Biochemistrysemantics logo
[EL] Γηριατρική[EN] Geriatricssemantics logo
[EL] Επιδημίες. Επιδημιολογία[EN] Epidemics. Epidemiologysemantics logo
Λέξεις-Κλειδιά: Aging
Biomarker
Cognitive frailty
Depression
GDF15
EU Grant: European Study to Establish Biomarkers of Human Ageing
f4f— food for the future
EU Grant identifier: 200880
491394008
031B0731E
Κάτοχος πνευματικών δικαιωμάτων: © 2023. The Author(s)
Ηλεκτρονική διεύθυνση στον εκδότη (link): https://doi.org/10.1007/s11357-023-00902-6
Σημειώσεις: The online version contains supplementary material available at https://doi.org/10.1007/s11357-023-00902-6.
Εμφανίζεται στις συλλογές:Ινστιτούτο Χημικής Βιολογίας - Επιστημονικό έργο

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