Εξειδίκευση τύπου :	Άρθρο σε επιστημονικό περιοδικό
Τίτλος:	Biomedical applications, perspectives and tag design concepts in the cell - silent Raman window
Δημιουργός/Συγγραφέας:	Vardaki, Martha Z [EL] Γρηγορίου, Βασίλης Γ.[EN] Gregoriou, Vasilis G. [EL] Χώχος, Χρήστος[EN] Chochos, Christos
Ημερομηνία:	2024-04-03
Γλώσσα:	Αγγλικά
DOI:	10.1039/d3cb00217a
Άλλο:	38576725
Περίληψη:	Spectroscopic studies increasingly employ Raman tags exhibiting a signal in the cell - silent region of the Raman spectrum (1800-2800 cm-1), where bands arising from biological molecules are inherently absent. Raman tags bearing functional groups which contain a triple bond, such as alkyne and nitrile or a carbon-deuterium bond, have a distinct vibrational frequency in this region. Due to the lack of spectral background and cell-associated bands in the specific area, the implementation of those tags can help overcome the inherently poor signal-to-noise ratio and presence of overlapping Raman bands in measurements of biological samples. The cell - silent Raman tags allow for bioorthogonal imaging of biomolecules with improved chemical contrast and they have found application in analyte detection and monitoring, biomarker profiling and live cell imaging. This review focuses on the potential of the cell - silent Raman region, reporting on the tags employed for biomedical applications using variants of Raman spectroscopy.
Τίτλος πηγής δημοσίευσης:	RSC chemical biology
Τόμος/Κεφάλαιο:	5
Τεύχος:	4
Θεματική Κατηγορία:	[EL] Χημική Βιολογία[EN] Chemical Biology [EL] Φασματοσκοπία[EN] Spectroscopy [EL] Βιοιατρική μηχανική. Ηλεκτρονική. Ενοργάνιση[EN] Biomedical engineering. Electronics. Instrumentation
Λέξεις-Κλειδιά:	Biomedical applications Raman spectroscopy
Κάτοχος πνευματικών δικαιωμάτων:	© 2024 The Author(s). Published by the Royal Society of Chemistry
Όροι και προϋποθέσεις δικαιωμάτων:	This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Ηλεκτρονική διεύθυνση στον εκδότη (link):	https://doi.org/10.1039/D3CB00217A
Εμφανίζεται στις συλλογές:	Ινστιτούτο Χημικής Βιολογίας - Επιστημονικό έργο