Εξειδίκευση τύπου :	Άρθρο σε επιστημονικό περιοδικό
Τίτλος:	Natural Compounds for Bone Remodeling: A Computational and Experimental Approach Targeting Bone Metabolism-Related Proteins
Δημιουργός/Συγγραφέας:	Loukas, Alexandros-Timotheos Papadourakis, Michail Panagiotopoulos, Vasilis Zarmpala, Apostolia Chontzopoulou, Eleni Christodoulou, Stephanos [EL] Κατσίλα, Θεοδώρα[EN] Katsila, Theodora [EL] Ζουμπουλάκης, Παναγιώτης[EN] Zoumpoulakis, Panagiotis Matsoukas, Minos-Timotheos
Ημερομηνία:	2024-05-06
Γλώσσα:	Αγγλικά
ISSN:	1422-0067
DOI:	10.3390/ijms25095047
Άλλο:	38732267
Περίληψη:	Osteoporosis, characterized by reduced bone density and increased fracture risk, affects over 200 million people worldwide, predominantly older adults and postmenopausal women. The disruption of the balance between bone-forming osteoblasts and bone-resorbing osteoclasts underlies osteoporosis pathophysiology. Standard treatment includes lifestyle modifications, calcium and vitamin D supplementation and specific drugs that either inhibit osteoclasts or stimulate osteoblasts. However, these treatments have limitations, including side effects and compliance issues. Natural products have emerged as potential osteoporosis therapeutics, but their mechanisms of action remain poorly understood. In this study, we investigate the efficacy of natural compounds in modulating molecular targets relevant to osteoporosis, focusing on the Mitogen-Activated Protein Kinase (MAPK) pathway and the gut microbiome's influence on bone homeostasis. Using an in silico and in vitro methodology, we have identified quercetin as a promising candidate in modulating MAPK activity, offering a potential therapeutic perspective for osteoporosis treatment.
Τίτλος πηγής δημοσίευσης:	International journal of molecular sciences
Τόμος/Κεφάλαιο:	25
Τεύχος:	9
Θεματική Κατηγορία:	[EL] Φυσιολογία[EN] Physiology [EL] Δημόσια υγεία. Υγιεινή. Προληπτική ιατρική[EN] Public health. Hygiene. Preventive medicine [EL] Βιοχημεία[EN] Biochemistry
Λέξεις-Κλειδιά:	osteoporosis natural compounds molecular docking molecular dynamics simulations bone metabolism quercetin MAPKs
EU Grant:	Competitiveness, Entrepreneurship and Innovation
EU Grant identifier:	T2EDK-03847
Κάτοχος πνευματικών δικαιωμάτων:	© 2024 by the authors. Licensee MDPI, Basel, Switzerland.
Όροι και προϋποθέσεις δικαιωμάτων:	This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
Ηλεκτρονική διεύθυνση στον εκδότη (link):	https://www.mdpi.com/1422-0067/25/9/5047
Εμφανίζεται στις συλλογές:	Ινστιτούτο Χημικής Βιολογίας - Επιστημονικό έργο