Εξειδίκευση τύπου :	Άρθρο σε επιστημονικό περιοδικό
Τίτλος:	Field-effect transistor antigen/antibody-TMDs sensors for the detection of COVID-19 samples
Δημιουργός/Συγγραφέας:	Canton-Vitoria, Ruben Sato, Kotaro Motooka, Yashiro Toyokuni, Shinya Liu, Zheng Kitaura, Ryo
Ημερομηνία:	2023-03-02
Γλώσσα:	Αγγλικά
DOI:	10.1039/d2nr06630k
Άλλο:	36762571
Περίληψη:	We fabricated sensors by modifying the surface of MoS2 and WS2 with COVID-19 antibodies and investigated their characteristics, including stability, reusability, sensitivity, and selectivity. Thiols and disulfanes in antibodies strongly interact with vacant Mo or W sites of MoS2 or WS2, yielding durable devices that are stable for several days in the air or water. More importantly, detachment of the antibodies is suppressed even during the aggressive cleaning process of the devices at pH 3, which allows reusing the same device in several experiments without appreciable loss of sensitivity. Therefore, the nanodevice may be employed in samples of different patients. Further, we found a limit of detection (LOD) of 1 fg ml-1 at room temperature, time responses of 1 second, and selectivity against interferences such as KLH protein or Albumin.
Τίτλος πηγής δημοσίευσης:	Nanoscale
Τόμος/Κεφάλαιο:	15
Τεύχος:	9
Σελίδες:	4570-4580
Θεματική Κατηγορία:	[EL] Φυσική και θεωρητική χημεία[EN] Physical and theoretical chemistry [EL] Νανοτεχνολογία[EN] Nanotechnology [EL] Δημόσια υγεία. Υγιεινή. Προληπτική ιατρική[EN] Public health. Hygiene. Preventive medicine
Λέξεις-Κλειδιά:	Humans Albumins Antibodies Limit of Detection Molybdenum Antigens COVID-19
EU Grant identifier:	JP21K18930 JP20H02566 JP22H05458 JP20H05664 JP21K18930 19F19368 JPMJCR16F3 JPMJCR19H4 JPMJPR20A2
Όροι και προϋποθέσεις δικαιωμάτων:	This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Ηλεκτρονική διεύθυνση στον εκδότη (link):	https://doi.org/10.1039/D2NR06630K
Σημειώσεις:	This work was supported by JSPS KAKENHI Grant Numbers JP21K18930, JP20H02566, JP22H05458, JP20H05664, 19F19368, JST CREST Grant Number JPMJCR16F3 and JPMJCR19H4, and JST PRESTO Grant Number JPMJPR20A2. Finally, we thank Kaori Asai for her proofreading.
Εμφανίζεται στις συλλογές:	Ινστιτούτο Θεωρητικής και Φυσικής Χημείας (ΙΘΦΧ) - Επιστημονικό έργο