Εξειδίκευση τύπου :	Άρθρο σε επιστημονικό περιοδικό
Τίτλος:	Deciphering the Lipid-Random Copolymer Interactions and Encoding Their Properties to Design a Hybrid System
Δημιουργός/Συγγραφέας:	Triantafyllopoulou, Efstathia Forys, Aleksander Perinelli, Diego Romano Balafouti, Anastasia Karayianni, Maria Trzebicka, Barbara Bonacucina, Giulia Valsami, Georgia Pippa, Natassa [EL] Πίσπας, Στέργιος[EN] Pispas, Stergios
Ημερομηνία:	2024-05-26
Γλώσσα:	Αγγλικά
ISSN:	0743-7463 1520-5827
DOI:	10.1021/acs.langmuir.4c00278
Άλλο:	38797979
Περίληψη:	Lipid/copolymer colloidal systems are deemed hybrid materials with unique properties and functionalities. Their hybrid nature leads to complex interfacial phenomena, which have not been fully encoded yet, navigating their properties. Moving toward in-depth knowledge of such systems, a comprehensive investigation of them is imperative. In the present study, hybrid lipid/copolymer structures were fabricated and examined by a gamut of techniques, including dynamic light scattering, fluorescence spectroscopy, cryogenic transmission electron microscopy, microcalorimetry, and high-resolution ultrasound spectroscopy. The biomaterials that were mixed for this purpose at different ratios were 1,2-dioctadecanoyl-sn-glycero-3-phosphocholine and four different linear, statistical (random) amphiphilic copolymers, consisting of oligo(ethylene glycol) methyl ether methacrylate as the hydrophilic comonomer and lauryl methacrylate as the hydrophobic one. The colloidal dispersions were studied for lipid/copolymer interactions regarding their physicochemical, morphological, and biophysical behavior. Their membrane properties and interactions with serum proteins were also studied. The aforementioned techniques confirmed the hybrid nature of the systems and the location of the copolymer in the structure. More importantly, the random architecture of the copolymers, the hydrophobic-to-hydrophilic balance of the nanoplatforms, and the lipid-to-polymer ratio are highlighted as the main design-influencing factors. Elucidating the lipid/copolymer interactions would contribute to the translation of hybrid nanoparticle performance and, thus, their rational design for multiple applications, including drug delivery.
Τίτλος πηγής δημοσίευσης:	Langmuir : the ACS journal of surfaces and colloids
Θεματική Κατηγορία:	[EL] Φυσική και θεωρητική χημεία[EN] Physical and theoretical chemistry [EL] Νανοτεχνολογία[EN] Nanotechnology
Λέξεις-Κλειδιά:	chemical structure copolymers hydrophobicity nanoparticles vesicles
Κάτοχος πνευματικών δικαιωμάτων:	© 2024 American Chemical Society
Ηλεκτρονική διεύθυνση στον εκδότη (link):	https://doi.org/10.1021/acs.langmuir.4c00278
Εμφανίζεται στις συλλογές:	Ινστιτούτο Θεωρητικής και Φυσικής Χημείας (ΙΘΦΧ) - Επιστημονικό έργο