Εξειδίκευση τύπου :	Άρθρο σε επιστημονικό περιοδικό
Τίτλος:	Ageladine A, a Bromopyrrole Alkaloid from the Marine Sponge Agelas nakamurai
Δημιουργός/Συγγραφέας:	[EL] Μαγουλάς, Γιώργος[EN] Magoulas, George
Ημερομηνία:	2023
Γλώσσα:	Αγγλικά
ISSN:	2673-6918
DOI:	10.3390/compounds3010010
Περίληψη:	During the last three decades, secondary metabolites of marine origin have emerged as a significant source of bioactive compounds. Among the marine organisms explored, sponges offer a vast number of metabolites with unique structural diversity and a plethora of biological activities. Ageladine A, a fluorescent bromopyrrole alkaloid isolated from the marine sponge Agelas nakamurai, exhibited matrix metalloproteinase (MMP) inhibitory properties, as well as antiangiogenic activity. Due to this interesting biological profile, Ageladine A became, soon after its discovery, a target for total synthesis. In addition, a significant number of derivatives have been synthesized, and their biological activity was evaluated. The present review highlights all the successful efforts made towards the synthesis of Ageladine A. Furthermore, all the medicinal chemistry approaches to identify and assess new more potent inhibitors and to elucidate the structural features responsible for the activity are described.
Τίτλος πηγής δημοσίευσης:	Compounds
Τόμος/Κεφάλαιο:	3
Τεύχος:	1
Θεματική Κατηγορία:	[EL] Βιοχημεία[EN] Biochemistry [EL] Φαρμακευτική χημεία[EN] Pharmaceutical chemistry [EL] Βιοτεχνολογία[EN] Biotechnology [EL] Χημική Βιολογία[EN] Chemical Biology
Λέξεις-Κλειδιά:	Marine natural products Ageladine A Total synthesis Agelas nakamurai MMP inhibitors Antiangiogenic activity Fluorescence
Κάτοχος πνευματικών δικαιωμάτων:	© 2023 by the author. Licensee MDPI, Basel, Switzerland.
Όροι και προϋποθέσεις δικαιωμάτων:	This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https:// creativecommons.org/licenses/by/ 4.0/).
Ηλεκτρονική διεύθυνση στον εκδότη (link):	https://doi.org/10.3390/compounds3010010
Εμφανίζεται στις συλλογές:	Ινστιτούτο Χημικής Βιολογίας - Επιστημονικό έργο