Εξειδίκευση τύπου :	Άρθρο σε επιστημονικό περιοδικό
Τίτλος:	Deregulated DNA damage response network in Behcet's disease
Δημιουργός/Συγγραφέας:	Vlachogiannis, Nikolaos I Ntouros, Panagiotis A Pappa, Maria Verrou, Kleio-Maria Arida, Aikaterini [EL] Σουλιώτης, Βασίλης Λ.[EN] Souliotis, Vassilis L. Sfikakis, Petros P
Ημερομηνία:	2023-01
Γλώσσα:	Αγγλικά
ISSN:	15216616
DOI:	10.1016/j.clim.2022.109189
Άλλο:	36400336
Περίληψη:	Behcet's disease (BD) is a chronic, relapsing systemic vasculitis of unknown etiology. Since the DNA repair enzyme NEIL1 has been identified as one of the two genetic risk factors for BD by whole exome study, we examined the potential involvement of the DNA damage response (DDR) network in BD. Peripheral blood mononuclear cells from 26 patients and 26 age-/sex-matched healthy controls were studied. Endogenous DNA damage levels were increased in active BD patients compared to controls or patients in remission. In parallel, BD patients had defective nucleotide excision repair capacity. RNA-sequencing revealed reduced expression of NEIL1 that negatively correlated with DNA damage accumulation. On the other hand, expression of genes involved in senescence and senescence-associated secretory phenotype positively correlated with individual endogenous DNA damage levels. We conclude that deregulated DDR contributes to the proinflammatory environment in BD.
Τίτλος πηγής δημοσίευσης:	Clinical immunology (Orlando, Fla.)
Τόμος/Κεφάλαιο:	246
Θεματική Κατηγορία:	[EL] Ανοσολογία[EN] Immunology [EL] Γενετική[EN] Genetics [EL] Βιοχημεία[EN] Biochemistry [EL] Μοριακή Βιολογία[EN] Molecular Biology
Λέξεις-Κλειδιά:	Behcet's disease DNA damage response DNA repair NEIL1 RNA sequencing
EU Grant:	pMedGR
EU Grant identifier:	MIS 5002802 0974
Κάτοχος πνευματικών δικαιωμάτων:	© 2022 Elsevier Inc. All rights reserved.
Ηλεκτρονική διεύθυνση στον εκδότη (link):	https://doi.org/10.1016/j.clim.2022.109189
Εμφανίζεται στις συλλογές:	Ινστιτούτο Χημικής Βιολογίας - Επιστημονικό έργο