Εξειδίκευση τύπου :	Άρθρο σε επιστημονικό περιοδικό
Τίτλος:	Biological Effects of Human Exposure to Environmental Cadmium
Δημιουργός/Συγγραφέας:	Peana, Massimiliano Pelucelli, Alessio [EL] Χασάπης, Χρήστος[EN] Chasapis, Christos Perlepes, Spyros P Bekiari, Vlasoula Medici, Serenella Zoroddu, Maria Antonietta
Ημερομηνία:	2022-12-24
Γλώσσα:	Αγγλικά
ISSN:	2218-273X
DOI:	10.3390/biom13010036
Άλλο:	36671421
Περίληψη:	Cadmium (Cd) is a toxic metal for the human organism and for all ecosystems. Cd is naturally found at low levels; however, higher amounts of Cd in the environment result from human activities as it spreads into the air and water in the form of micropollutants as a consequence of industrial processes, pollution, waste incineration, and electronic waste recycling. The human body has a limited ability to respond to Cd exposure since the metal does not undergo metabolic degradation into less toxic species and is only poorly excreted. The extremely long biological half-life of Cd essentially makes it a cumulative toxin; chronic exposure causes harmful effects from the metal stored in the organs. The present paper considers exposure and potential health concerns due to environmental cadmium. Exposure to Cd compounds is primarily associated with an elevated risk of lung, kidney, prostate, and pancreatic cancer. Cd has also been linked to cancers of the breast, urinary system, and bladder. The multiple mechanisms of Cd-induced carcinogenesis include oxidative stress with the inhibition of antioxidant enzymes, the promotion of lipid peroxidation, and interference with DNA repair systems. Cd2+ can also replace essential metal ions, including redox-active ones. A total of 12 cancer types associated with specific genes coding for the Cd-metalloproteome were identified in this work. In addition, we summarize the proper treatments of Cd poisoning, based on the use of selected Cd detoxifying agents and chelators, and the potential for preventive approaches to counteract its chronic exposure.
Τίτλος πηγής δημοσίευσης:	Biomolecules
Τόμος/Κεφάλαιο:	13
Τεύχος:	1
Θεματική Κατηγορία:	[EL] Νεοπλάσματα. Όγκοι. Ογκολογία (περ. Καρκίνος, κακινογόνες ουσίες)[EN] Neoplasms. Tumors. Oncology (Incl.cancer, carcinogens) [EL] Ιατρική-Δημόσια υγεία[EN] Medicine - public aspects [EL] Χημική Βιολογία[EN] Chemical Biology [EL] Τοξικολογία[EN] Toxicology. Poisons
Λέξεις-Κλειδιά:	cadmium cadmium toxicity cadmium exposure chronic exposure protein targets
EU Grant:	Fondo di Ateneo per la ricerca 2019, FAR 2019 Fondo di Ateneo per la ricerca 2020, FAR 2020
EU Grant identifier:	Rep. 2467, Prot. 94737 07/08/2019 Rep. 2465, Prot. 0097985 01/09/2020
Κάτοχος πνευματικών δικαιωμάτων:	© 2022 by the authors. Licensee MDPI, Basel, Switzerland.
Όροι και προϋποθέσεις δικαιωμάτων:	This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https:// creativecommons.org/licenses/by/ 4.0/).
Ηλεκτρονική διεύθυνση στον εκδότη (link):	https://doi.org/10.3390/biom13010036
Εμφανίζεται στις συλλογές:	Ινστιτούτο Χημικής Βιολογίας - Επιστημονικό έργο