Εξειδίκευση τύπου :	Άρθρο σε επιστημονικό περιοδικό
Τίτλος:	DNA Damage Response Mechanisms in Head and Neck Cancer: Significant Implications for Therapy and Survival
Δημιουργός/Συγγραφέας:	Papalouka, Chara Adamaki, Maria Batsaki, Panagiota Zoumpourlis, Panagiotis Tsintarakis, Antonis Goulielmaki, Maria Fortis, Sotirios P Baxevanis, Constantin N [EL] Ζουμπουρλής, Βασίλης[EN] Zoumpourlis, Vassilis
Ημερομηνία:	2023-02-01
Γλώσσα:	Αγγλικά
ISSN:	1422-0067
DOI:	10.3390/ijms24032760
Άλλο:	36769087
Περίληψη:	Head and neck cancer (HNC) is a term collectively used to describe a heterogeneous group of tumors that arise in the oral cavity, larynx, nasopharynx, oropharynx, and hypopharynx, and represents the sixth most common type of malignancy worldwide. Despite advances in multimodality treatment, the disease has a recurrence rate of around 50%, and the prognosis of metastatic patients remains poor. HNCs are characterized by a high degree of genomic instability, which involves a vicious circle of accumulating DNA damage, defective DNA damage repair (DDR), and replication stress. Nonetheless, the damage that is induced on tumor cells by chemo and radiotherapy relies on defective DDR processes for a successful response to treatment, and may play an important role in the development of novel and more effective therapies. This review summarizes the current knowledge on the genes and proteins that appear to be deregulated in DDR pathways, their implication in HNC pathogenesis, and the rationale behind targeting these genes and pathways for the development of new therapies. We give particular emphasis on the therapeutic targets that have shown promising results at the pre-clinical stage and on those that have so far been associated with a therapeutic advantage in the clinical setting.
Τίτλος πηγής δημοσίευσης:	International journal of molecular sciences
Τόμος/Κεφάλαιο:	24
Τεύχος:	3
Θεματική Κατηγορία:	[EL] Βιοχημεία[EN] Biochemistry [EL] Νεοπλάσματα. Όγκοι. Ογκολογία (περ. Καρκίνος, κακινογόνες ουσίες)[EN] Neoplasms. Tumors. Oncology (Incl.cancer, carcinogens) [EL] Μοριακή Βιολογία[EN] Molecular Biology [EL] Γενετική[EN] Genetics
Λέξεις-Κλειδιά:	DNA damage response genomic instability head and neck cancer (HNC) head and neck squamous cell carcinoma (HNSCC) homologous recombination (HR) non-homologous end joining (NHEJ)
EU Grant:	BIOKAKETRA—Identification of genomic and tran-scriptomic prognostic bio-signatures in head and neck cancer
EU Grant identifier:	T2EDK-03266
Κάτοχος πνευματικών δικαιωμάτων:	© 2023 by the authors. Licensee MDPI, Basel, Switzerland.
Όροι και προϋποθέσεις δικαιωμάτων:	This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https:// creativecommons.org/licenses/by/ 4.0/).
Ηλεκτρονική διεύθυνση στον εκδότη (link):	https://doi.org/10.3390/ijms24032760
Εμφανίζεται στις συλλογές:	Ινστιτούτο Χημικής Βιολογίας - Επιστημονικό έργο