Εξειδίκευση τύπου :	Άρθρο σε επιστημονικό περιοδικό
Τίτλος:	Comprehensive characterization of the neurogenic and neuroprotective action of a novel TrkB agonist using mouse and human stem cell models of Alzheimer's disease
Δημιουργός/Συγγραφέας:	Charou, Despoina Rogdakis, Thanasis Latorrata, Alessia Valcarcel, Maria Papadogiannis, Vasileios Athanasiou, Christina Tsengenes, Alexandros Papadopoulou, Maria Anna Lypitkas, Dimitrios Lavigne, Matthieu D [EL] Κατσίλα, Θεοδώρα[EN] Katsila, Theodora Wade, Rebecca C Cader, M Zameel [EL] Καλογεροπούλου, Θεοδώρα[EN] Calogeropoulou, Theodora Gravanis, Achille Charalampopoulos, Ioannis
Ημερομηνία:	2024-07-06
Γλώσσα:	Αγγλικά
ISSN:	1757-6512
DOI:	10.1186/s13287-024-03818-w
Άλλο:	38971770
Περίληψη:	Neural stem cell (NSC) proliferation and differentiation in the mammalian brain decreases to minimal levels postnatally. Nevertheless, neurogenic niches persist in the adult cortex and hippocampus in rodents, primates and humans, with adult NSC differentiation sharing key regulatory mechanisms with development. Adult neurogenesis impairments have been linked to Alzheimer's disease (AD) pathology. Addressing these impairments by using neurotrophic factors is a promising new avenue for therapeutic intervention based on neurogenesis. However, this possibility has been hindered by technical difficulties of using in-vivo models to conduct screens, including working with scarce NSCs in the adult brain and differences between human and mouse models or ethical limitations.
Τίτλος πηγής δημοσίευσης:	Stem cell research & therapy
Τόμος/Κεφάλαιο:	15
Τεύχος:	1
Θεματική Κατηγορία:	[EL] Βιοχημεία[EN] Biochemistry [EL] Κυτταρολογία[EN] Cytology [EL] Βιοτεχνολογία[EN] Biotechnology [EL] Εσωτερική ιατρική[EN] Internal medicine [EL] Φαρμακευτική χημεία[EN] Pharmaceutical chemistry
Λέξεις-Κλειδιά:	Alzheimer’s disease (AD) BDNF In-vitro drug testing Neurogenesis Stem-cell based screening TrkB Induced pluripotent stem cells (iPSC)
EU Grant:	Marie SkłodowskaCurie SoftReach
EU Grant identifier:	No 765704 No 101099145
Κάτοχος πνευματικών δικαιωμάτων:	© 2024. The Author(s).
Όροι και προϋποθέσεις δικαιωμάτων:	Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
Ηλεκτρονική διεύθυνση στον εκδότη (link):	https://doi.org/10.1186/s13287-024-03818-w
Σημειώσεις:	This work was supported by grants from: 1. the European Union’s Horizon 2020 research and innovation programme under the Marie SkłodowskaCurie grant agreement (No 765704 to D.C., T.C., C.A., R.W., A.G. and I.C.). 2. the European Union HORIZON, under the European Innovation Council (EIC)- 2022-PATHFINDEROPEN-01 program “SoftReach” (No 101099145 to D.C., A.G., I.C.). 3. the Institute of Pharmaceutical Research and Technology (IFET S.A.) under collaborative funding between FORTH and IFET S.A.
Εμφανίζεται στις συλλογές:	Ινστιτούτο Χημικής Βιολογίας - Επιστημονικό έργο