Εξειδίκευση τύπου :	Άρθρο σε επιστημονικό περιοδικό
Τίτλος:	Protein-induced transformation of unilamellar to multilamellar vesicles triggered by a polysaccharide
Δημιουργός/Συγγραφέας:	[EL] Παπαγιαννόπουλος, Αριστείδης[EN] Papagiannopoulos, Aristeidis Sklapani, Aggeliki Len, Adél Radulescu, Aurel Pavlova, Ewa Slouf, Miroslav
Ημερομηνία:	2023-03-01
Γλώσσα:	Αγγλικά
ISSN:	01448617
DOI:	10.1016/j.carbpol.2022.120478
Άλλο:	36657851
Περίληψη:	We report on the morphological transitions of didodecyldimethylammonium bromide (DDAB) cationic vesicles and hybrid DDAB/hyaluronic acid (HA) vesicles upon addition of BSA at pH 7 where BSA is overall negatively charged. Small angle neutron scattering (SANS) is used to extract the size distributions of the nanovesicles, the thickness of the DDAB bilayers and their lamellarity. Although the HA-decorated DDAB vesicles contain the negatively charged polysaccharide the interaction with BSA appears to be more intense in comparison to bare vesicles. Characteristic peaks in the SANS patterns indicate the presence of multilamellar interfaces while the formation of multilamellar vesicles induced by BSA depends on the amount of added HA. Consequently, higher lamellarities are observed at higher BSA contents. This work demonstrates a simple methodology to tune the encapsulation of globular proteins in vesicular nanoassemblies by affecting their lamellarity and has direct implications on the application of vesicles and liposomes in protein delivery.
Τίτλος πηγής δημοσίευσης:	Carbohydrate polymers
Τόμος/Κεφάλαιο:	303
Θεματική Κατηγορία:	[EL] Φυσική και θεωρητική χημεία[EN] Physical and theoretical chemistry
Λέξεις-Κλειδιά:	bovine serum albumin didodecyldimethylammonium bromide hyaluronic acid small angle neutron scattering
Ηλεκτρονική διεύθυνση στον εκδότη (link):	https://doi.org/10.1016/j.carbpol.2022.120478
Εμφανίζεται στις συλλογές:	Ινστιτούτο Θεωρητικής και Φυσικής Χημείας (ΙΘΦΧ) - Επιστημονικό έργο