Εξειδίκευση τύπου :	Κεφάλαιο βιβλίου
Τίτλος:	Chemically Functionalized Carbon Nanohorns for Drug Delivery Applications
Δημιουργός/Συγγραφέας:	Stangel, Christina [EL] Ταγματάρχης, Νίκος[EN] Tagmatarchis, Nikos
Εκδότης:	Taylor and Francis
Ημερομηνία:	2023
Γλώσσα:	Αγγλικά
ISBN:	978-100341146-8 978-981496865-2
Περίληψη:	Carbon nanohorns (CNHs) have been widely researched for drug delivery, due to their large surface area, abundance of conical interstice sites, stability, and negligible toxicity in animal testing. A plethora of anticancer drugs or biomolecules has been grafted covalently onto CNHs for the creation of efficient drug delivery systems (DDS). The filling of the inner cavity of CNHs with biomolecules or drugs as well as the immobilization of bioactive molecules onto the side walls of CNHs is a common non-covalent strategy for the development of effective delivery nanocarriers. In this chapter, the authors summarized the recent development of functionalized CNHs as intelligent drug carriers for the delivery of anticancer drugs and other biologically active compounds in vitro and in vivo. It should be mentioned that despite the very encouraging results obtained from in vitro models, the lack of adequate studies using appropriate in vivo models strongly limits the current understanding of how these nanomaterials act in biological systems.
Τίτλος πηγής δημοσίευσης:	Functional Materials in Biomedical Applications
Τόμος/Κεφάλαιο:	7
Σελίδες:	311-340
Θεματική Κατηγορία:	[EL] Νανοτεχνολογία[EN] Nanotechnology [EL] Φαρμακευτική[EN] Pharmacy and materia medica
Λέξεις-Κλειδιά:	Carbon nanohorns (CNHs) Drug delivery systems (DDS)
Ηλεκτρονική διεύθυνση στον εκδότη (link):	https://www.taylorfrancis.com/chapters/edit/10.1201/9781003411468-7
Εμφανίζεται στις συλλογές:	Ινστιτούτο Θεωρητικής και Φυσικής Χημείας (ΙΘΦΧ) - Επιστημονικό έργο