Εξειδίκευση τύπου :	Άρθρο σε επιστημονικό περιοδικό
Τίτλος:	Circulatory Metabolite Ratios as Indicators of Lifestyle Risk Factors Based on a Greek NAFLD Case-Control Study
Δημιουργός/Συγγραφέας:	Fotakis, Charalambos Amanatidou, Athina I Kafyra, Maria Andreou, Vasiliki Kalafati, Ioanna Panagiota [EL] Ζερβού, Μαρία[EN] Zervou, Maria Dedoussis, George V
Ημερομηνία:	2024-04-21
Γλώσσα:	Αγγλικά
ISSN:	2072-6643
DOI:	10.3390/nu16081235
Άλλο:	38674925
Περίληψη:	An ensemble of confounding factors, such as an unhealthy diet, obesity, physical inactivity, and smoking, have been linked to a lifestyle that increases one's susceptibility to chronic diseases and early mortality. The circulatory metabolome may provide a rational means of pinpointing the advent of metabolite variations that reflect an adherence to a lifestyle and are associated with the occurrence of chronic diseases. Data related to four major modifiable lifestyle factors, including adherence to the Mediterranean diet (estimated on MedDietScore), body mass index (BMI), smoking, and physical activity level (PAL), were used to create the lifestyle risk score (LS). The LS was further categorized into four groups, where a higher score group indicates a less healthy lifestyle. Drawing on this, we analyzed 223 NMR serum spectra, 89 MASLD patients and 134 controls; these were coupled to chemometrics to identify "key" features and understand the biological processes involved in specific lifestyles. The unsupervised analysis verified that lifestyle was the factor influencing the samples' differentiation, while the supervised analysis highlighted metabolic signatures. Τhe metabolic ratios of alanine/formic acid and leucine/formic acid, with AUROC > 0.8, may constitute discriminant indexes of lifestyle. On these grounds, this research contributed to understanding the impact of lifestyle on the circulatory metabolome and highlighted "prudent lifestyle" biomarkers.
Τίτλος πηγής δημοσίευσης:	Nutrients
Τόμος/Κεφάλαιο:	16
Τεύχος:	8
Θεματική Κατηγορία:	[EL] Δημόσια υγεία. Υγιεινή. Προληπτική ιατρική[EN] Public health. Hygiene. Preventive medicine [EL] Βιοχημεία[EN] Biochemistry [EL] Επιδημίες. Επιδημιολογία[EN] Epidemics. Epidemiology
Λέξεις-Κλειδιά:	MASLD Serum NMR metabolomics Lifestyle Obesity Metabolite biomarkers
EU Grant:	Competitiveness, Entrepreneurship and Innovation
EU Grant identifier:	T2EDK-03044
Κάτοχος πνευματικών δικαιωμάτων:	© 2024 by the authors. Licensee MDPI, Basel, Switzerland.
Όροι και προϋποθέσεις δικαιωμάτων:	This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https:// creativecommons.org/licenses/by/ 4.0/).
Ηλεκτρονική διεύθυνση στον εκδότη (link):	https://doi.org/10.3390/nu16081235
Εμφανίζεται στις συλλογές:	Ινστιτούτο Χημικής Βιολογίας - Επιστημονικό έργο