Εξειδίκευση τύπου :	Άρθρο σε επιστημονικό περιοδικό
Τίτλος:	Zinc and its binding proteins: essential roles and therapeutic potential
Δημιουργός/Συγγραφέας:	Kiouri, Despoina P [EL] Χασάπης, Χρήστος[EN] Chasapis, Christos [EL] Μαυρομούστακος, Θωμάς[EN] Mavromoustakos, Thomas Spiliopoulou, Chara A Stefanidou, Maria E
Ημερομηνία:	2024-11-07
Γλώσσα:	Αγγλικά
ISSN:	0340-5761 1432-0738
DOI:	10.1007/s00204-024-03891-3
Άλλο:	39508885
Περίληψη:	Zinc is an essential micronutrient that participates in a multitude of cellular and biochemical processes. It is indispensable for normal growth and the maintenance of physiological functions. As one of the most significant trace elements in the body, zinc fulfills three primary biological roles: catalytic, structural, and regulatory. It serves as a cofactor in over 300 enzymes, and more than 3000 proteins require zinc, underscoring its crucial role in numerous physiological processes such as cell division and growth, immune function, tissue maintenance, as well as synthesis protein and collagen synthesis. Zinc deficiency has been linked to increased oxidative stress and inflammation, which may contribute to the pathogenesis of a multitude of diseases, like neurological disorders and cancer. In addition, zinc is a key constituent of zinc-binding proteins, which play a pivotal role in maintaining cellular zinc homeostasis. This review aims to update and expand upon the understanding of zinc biology, highlighting the fundamental roles of zinc in biological processes and the health implications of zinc deficiency. This work also explores the diverse functions of zinc in immune regulation, cellular growth, and neurological health, emphasizing the need for further research to fully elucidate the therapeutic potential of zinc supplementation in disease prevention and management.
Τίτλος πηγής δημοσίευσης:	Archives of toxicology
Θεματική Κατηγορία:	[EL] Βιοχημεία[EN] Biochemistry [EL] Φυσιολογία[EN] Physiology [EL] Δομική Βιολογία[EN] Structural Biology [EL] Ιατρική (Γενικά)[EN] Medicine (General) [EL] Θεραπευτική. Φαρμακολογία[EN] Therapeutics.Pharmacology
Λέξεις-Κλειδιά:	COVID-19 cancer neurodegenerative diseases zinc zinc deficiency zinc finger proteins
Κάτοχος πνευματικών δικαιωμάτων:	© The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2024
Ηλεκτρονική διεύθυνση στον εκδότη (link):	https://doi.org/10.1007/s00204-024-03891-3
Εμφανίζεται στις συλλογές:	Ινστιτούτο Χημικής Βιολογίας - Επιστημονικό έργο