Εξειδίκευση τύπου :	Άρθρο σε επιστημονικό περιοδικό
Τίτλος:	Lifelong dietary protein restriction induces denervation and skeletal muscle atrophy in mice
Δημιουργός/Συγγραφέας:	Ersoy, Ufuk Altinpinar, Atilla Emre Kanakis, Ioannis Alameddine, Moussira Gioran, Anna [EL] Χονδρογιάννη, Νίκη[EN] Chondrogianni, Niki Ozanne, Susan E Peffers, Mandy Jayne Jackson, Malcolm J Goljanek-Whysall, Katarzyna Vasilaki, Aphrodite
Ημερομηνία:	2024-11-01
Γλώσσα:	Αγγλικά
ISSN:	08915849
DOI:	10.1016/j.freeradbiomed.2024.09.005
Άλλο:	39245354
Περίληψη:	As a widespread global issue, protein deficiency hinders development and optimal growth in offspring. Maternal low-protein diet influences the development of age-related diseases, including sarcopenia, by altering the epigenome and organ structure through potential increase in oxidative stress. However, the long-term effects of lactational protein restriction or postnatal lifelong protein restriction on the neuromuscular system have yet to be elucidated. Our results demonstrated that feeding a normal protein diet after lactational protein restriction did not have significant impacts on the neuromuscular system in later life. In contrast, a lifelong low-protein diet induced a denervation phenotype and led to demyelination in the sciatic nerve, along with an increase in the number of centralised nuclei and in the gene expression of atrogenes at 18 months of age, indicating an induced skeletal muscle atrophy. These changes were accompanied by an increase in proteasome activity in skeletal muscle, with no significant alterations in oxidative stress or mitochondrial dynamics markers in skeletal muscle later in life. Thus, lifelong protein restriction may induce skeletal muscle atrophy through changes in peripheral nerves and neuromuscular junctions, potentially contributing to the early onset or exaggeration of sarcopenia.
Τίτλος πηγής δημοσίευσης:	Free radical biology & medicine
Τόμος/Κεφάλαιο:	224
Θεματική Κατηγορία:	[EL] Φυσιολογία[EN] Physiology [EL] Βιοχημεία[EN] Biochemistry [EL] Ιατρική[EN] Medicine
Λέξεις-Κλειδιά:	atrophy denervation oxidative stress protein restriction poteostasis skeletal muscle
Κάτοχος πνευματικών δικαιωμάτων:	© 2024 The Authors. Published by Elsevier Inc.
Όροι και προϋποθέσεις δικαιωμάτων:	This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
Ηλεκτρονική διεύθυνση στον εκδότη (link):	https://doi.org/10.1016/j.freeradbiomed.2024.09.005
Εμφανίζεται στις συλλογές:	Ινστιτούτο Χημικής Βιολογίας - Επιστημονικό έργο