Εξειδίκευση τύπου :	Άρθρο σε επιστημονικό περιοδικό
Τίτλος:	Association between TTV viremia, chronic inflammation, and ischemic heart disease risk: Insights from MARK-AGE and Report-Age projects
Δημιουργός/Συγγραφέας:	Giacconi, Robertina Piacenza, Francesco Maggi, Fabrizio Bürkle, Alexander Moreno Villanueva, María Mancinelli, Lucia Spezia, Pietro Giorgio Novazzi, Federica Drago Ferrante, Francesca Minosse, Claudia Grossi, Paolo Antonio Mancini, Nicasio Cecati, Monia Dollé, Martijn E T Jansen, Eugène Grune, Tilman [EL] Γκόνος, Ευστάθιος[EN] Gonos, Efstathios S. Franceschi, Claudio Capri, Miriam Weinberger, Birgit Sikora, Ewa Debacq-Chainiaux, Florence Stuetz, Wolfgang Hurme, Mikko Slagboom, P Eline Bernhardt, Jürgen Gentilini, Davide Calzari, Luciano Di Rosa, Mirko Bonfigli, Anna Rita Galeazzi, Roberta Cherubini, Antonio Lattanzio, Fabrizia Provinciali, Mauro Malavolta, Marco
Ημερομηνία:	2024-10-24
Γλώσσα:	Αγγλικά
ISSN:	1079-5006 1758-535X
DOI:	10.1093/gerona/glae228
Άλλο:	39446526
Περίληψη:	The implication of Torquetenovirus (TTV) in Ischemic Heart Disease (IHD) has not been thoroughly explored. This study investigated the association between TTV viremia, proinflammatory cytokines, and IHD risk in an aging population. This cross-sectional study included 900 non-IHD subjects (NIHD) and 86 individuals with IHD (aged 55 to 75 years) selected from the MARK-AGE project. Results were verified in another independent Report-Age cohort, including 94 inpatients with chronic IHD and 111 inpatients with no evidence of IHD (NIHD) (aged 65 to 96 years). Multivariable logistic regression in the MARK-AGE cohort revealed that male sex, TTV viremia ≥4log, Cu/Zn ratio, diabetes, hypertension and smoking were significant IHD predictors. Notably, TTV viremia ≥4log independently increased the IHD risk (OR: 2.51, 95% CI: 1.42-4.43), confirmed in the Report-Age cohort (OR: 4.90, 95% CI: 2.32-10.39). In a RASIG subgroup, individuals with TTV viremia ≥4log, both with and without IHD, exhibited increased plasma pro-inflammatory cytokine levels (IFN-γ, IL-1β, IL-6, IL-10, IL-12p70, TNF-α) compared to those with TTV viremia < 4log. No significant difference in cytokine production was observed between IHD patients and NIHD with TTV viremia ≥4log. A positive correlation between TTV viremia and DNA methylation estimator of leukocyte telomere length was observed in Report-Age patients. Additionally, IHD Report-Age patients with TTV viremia ≥4log displayed higher NLR and SIRI index than those with TTV viremia < 4log. In conclusion, a high TTV viremia is associated with an elevated IHD risk in the older population, potentially arising from an augmented proinflammatory response and immunosenescence.
Τίτλος πηγής δημοσίευσης:	The journals of gerontology. Series A, Biological sciences and medical sciences
Θεματική Κατηγορία:	[EL] Ιολογία[EN] Virology [EL] Ανοσολογία[EN] Immunology [EL] Γηριατρική[EN] Geriatrics [EL] Βιοχημεία[EN] Biochemistry [EL] Επιδημίες. Επιδημιολογία[EN] Epidemics. Epidemiology
Λέξεις-Κλειδιά:	Ischemic Heart Disease Torquetenovirus aging inflammation
Κάτοχος πνευματικών δικαιωμάτων:	© The Author(s) 2024. Published by Oxford University Press on behalf of The Gerontological Society of America.
Όροι και προϋποθέσεις δικαιωμάτων:	This is an Open Access article distributed under the terms of the Creative Commons AttributionNonCommercial-NoDerivs licence (https://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact reprints@oup.com for reprints and translation rights for reprints. All other permissions can be obtained through our RightsLink service via the Permissions link on the article page on our site— for further information please contact journals.permissions@oup.com.
Ηλεκτρονική διεύθυνση στον εκδότη (link):	https://doi.org/10.1093/gerona/glae228
Σημειώσεις:	This is the accepted version of the article. Accepted manuscripts are PDF versions of the author’s final manuscript, as accepted for publication by the journal but prior to copyediting or typesetting. They can be cited using the author(s), article title, journal title, year of online publication, and DOI. They will be replaced by the final typeset articles, which may therefore contain changes. The DOI will remain the same throughout.
Εμφανίζεται στις συλλογές:	Ινστιτούτο Χημικής Βιολογίας - Επιστημονικό έργο