Εξειδίκευση τύπου :	Άρθρο σε επιστημονικό περιοδικό
Τίτλος:	Identification of a Novel Immune-Gene Signature with Prognostic Value in Patients with Head and Neck Cancer: A Pilot Study
Δημιουργός/Συγγραφέας:	Batsaki, Panagiota Fortis, Sotirios P Gritzapis, Angelos D Razou, Andriana Sakellaridis, Athanasios C Grouzi, Elisavet Moschandreou, Dimitra Koukourakis, Michael I [EL] Ζουμπουρλής, Βασίλης[EN] Zoumpourlis, Vassilis Baxevanis, Constantin N Goulielmaki, Maria
Ημερομηνία:	2025-01-08
Γλώσσα:	Αγγλικά
ISSN:	0006-2928 1573-4927
DOI:	10.1007/s10528-024-11017-8
Άλλο:	39779579
Περίληψη:	The tumor microenvironment has a significant input on prognosis and also for predicting clinical outcomes in various types of cancers. However, tumor tissue is not always available, thus, rendering peripheral blood a preferable alternative in the search for prognostic and predictive gene signatures. Head and neck squamous cell carcinoma (HNSCC) constitutes a quite heterogeneous disease characterized by poor prognosis. Therefore, the discovery of novel therapeutics based on prognostic gene signatures for effective disease governance is of paramount importance. In this study, we report for the first time an immune-gene signature identified in the peripheral blood of HNSCC patients comprising five genes (CLEC4C, IL23A, LCK, LY9, and CD19) which were more than threefold downregulated as compared to healthy individuals and were associated with poor prognosis. By performing analyses of HNSCC tumor samples from The Cancer Genome Atlas (TCGA) database, we discovered that decreased expression of these genes, both as single genes and as a 5-gene signature (5-GS), was significantly correlated with worse overall survival (OS). Our data show that the levels of expression of the 5-GS represent an immune profile predicting OS in patients with HNSCC.
Τίτλος πηγής δημοσίευσης:	Biochemical genetics
Θεματική Κατηγορία:	[EL] Νεοπλάσματα. Όγκοι. Ογκολογία (περ. Καρκίνος, κακινογόνες ουσίες)[EN] Neoplasms. Tumors. Oncology (Incl.cancer, carcinogens) [EL] Ανοσολογία[EN] Immunology [EL] Βιοχημεία[EN] Biochemistry [EL] Μοριακή Βιολογία[EN] Molecular Biology
Λέξεις-Κλειδιά:	5-gene signature gene expression head and neck cancer (HNC) peripheral blood prognostic biomarkers cancer genome atlas
Κάτοχος πνευματικών δικαιωμάτων:	© 2025. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.
Ηλεκτρονική διεύθυνση στον εκδότη (link):	https://doi.org/10.1007/s10528-024-11017-8
Εμφανίζεται στις συλλογές:	Ινστιτούτο Χημικής Βιολογίας - Επιστημονικό έργο