Εξειδίκευση τύπου :	Άρθρο σε επιστημονικό περιοδικό
Τίτλος:	An expert consensus statement on biomarkers of ageing for use in intervention studies
Δημιουργός/Συγγραφέας:	Perri, Giorgia French, Chloe Agostinis-Sobrinho, César Anand, Atul Antarianto, Radiana Dhewayani Arai, Yasumichi Baur, Joseph A Cauli, Omar Clivaz-Duc, Morgane Colloca, Giuseppe Demetriades, Constantinos de Lucia, Chiara Di Gessa, Giorgio Diniz, Breno S Dotchin, Catherine L Eaglestone, Gillian Elliott, Bradley T Espeland, Mark A Ferrucci, Luigi Fisher, James Grammatopoulos, Dimitris K Hardiany, Novi S Hassan-Smith, Zaki Hastings, Waylon J Jain, Swati Joshi, Peter K [EL] Κατσίλα, Θεοδώρα[EN] Katsila, Theodora Kemp, Graham J Khaiyat, Omid A Lamming, Dudley W Gallegos, Jose Lara Madeo, Frank Maier, Andrea B Martin-Ruiz, Carmen Martins, Ian J Mathers, John C Mattin, Lewis R Merchant, Reshma A Moskalev, Alexey Neytchev, Ognian Ni Lochlainn, Mary Owen, Claire M Phillips, Stuart M Pratt, Jedd Prokopidis, Konstantinos Rattray, Nicholas J W Rúa-Alonso, María Schomburg, Lutz Scott, David Shyam, Sangeetha Sillanpää, Elina Tan, Michelle M C Teh, Ruth Tobin, Stephanie W Vila-Chã, Carolina J Vorluni, Luigi Weber, Daniela Welch, Ailsa Wilson, Daisy Wilson, Thomas Zhao, Tongbiao Philippou, Elena Korolchuk, Viktor I Shannon, Oliver M
Ημερομηνία:	2024-12-21
Γλώσσα:	Αγγλικά
ISSN:	1079-5006 1758-535X
DOI:	10.1093/gerona/glae297
Άλλο:	39708300
Περίληψη:	Biomarkers of ageing serve as important outcome measures in longevity-promoting interventions. However, there is limited consensus on which specific biomarkers are most appropriate for human intervention studies. This work aimed to address this need by establishing an expert consensus on biomarkers of ageing for use in intervention studies via the Delphi method. A three-round Delphi study was conducted using an online platform. In Round 1, expert panel members provided suggestions for candidate biomarkers of ageing. In Rounds 2 and 3, they voted on 500 initial statements (yes/no) relating to 20 biomarkers of ageing. Panel members could abstain from voting on biomarkers outside their expertise. Consensus was reached when there was ≥70% agreement on a statement/biomarker. Of the 460 international panel members invited to participate, 116 completed Round 1, 87 completed Round 2, and 60 completed Round 3. Across the 3 rounds, 14 biomarkers met consensus that spanned physiological (e.g., insulin-like growth factor 1, growth-differentiating factor-15), inflammatory (e.g., high sensitivity c-reactive protein, interleukin-6), functional (e.g., muscle mass, muscle strength, hand grip strength, Timed-Up-and-Go, gait speed, standing balance test, frailty index, cognitive health, blood pressure), and epigenetic (e.g., DNA methylation/epigenetic clocks) domains. Expert consensus identified 14 potential biomarkers of ageing which may be used as outcome measures in intervention studies. Future ageing research should identify which combination of these biomarkers has the greatest utility.
Τίτλος πηγής δημοσίευσης:	The journals of gerontology. Series A, Biological sciences and medical sciences
Θεματική Κατηγορία:	[EL] Γηριατρική[EN] Geriatrics [EL] Βιοχημεία[EN] Biochemistry
Λέξεις-Κλειδιά:	Delphi method consensus longevity
Κάτοχος πνευματικών δικαιωμάτων:	© The Author(s) 2024. Published by Oxford University Press on behalf of the Gerontological Society of America.
Όροι και προϋποθέσεις δικαιωμάτων:	This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
Ηλεκτρονική διεύθυνση στον εκδότη (link):	https://doi.org/10.1093/gerona/glae297
Εμφανίζεται στις συλλογές:	Ινστιτούτο Χημικής Βιολογίας - Επιστημονικό έργο