Εξειδίκευση τύπου :	Άρθρο σε επιστημονικό περιοδικό
Τίτλος:	Microsatellite instability in patients with chronic obstructive pulmonary disease
Δημιουργός/Συγγραφέας:	[EL] Σπαντίδος, Δημήτριος Α.[EN] Spandidos, Demetrios A. Ergazaki, M. Hatzistamou, J. Kiaris, H. Bouros, D. Tzortzaki, E. G. Siafakas, N. M.
Εκδότης:	Demetrios A. Spandidos Ed. & Pub.
Ημερομηνία:	1996
Γλώσσα:	Αγγλικά
ISSN:	1021-335X
Περίληψη:	Chronic obstructive pulmonary disease (COPD) is a relatively common disease, affecting mainly males in the western world. Although substantial data are available as regards the clinicopathological characterization of COPD, little is known of the molecular basis of the disease. In the present study we analysed the incidence of microsatellite instability (MI) in cytological specimens from patients with COPD. MI reflects increased mutational rate and is associated with decreased accuracy in the DNA repair, resulting in the accumulation of somatic mutations in cells manifesting this genetic alteration. Among 31 specimens tested, 7 (23%) exhibited MI in at least one among 6 microsatellite markers tested. 5 cases were affected in only one marker while the remaining two cases exhibited evidence of MI in two microsatellite markers. These data suggest that an elevated mutational rate as reflected by the increased incidence of MI is associated with the development of the disease.
Τίτλος πηγής δημοσίευσης:	Oncology Reports
Τόμος/Κεφάλαιο:	3
Τεύχος:	3
Σελίδες:	489-491
Αξιολόγηση από ομότιμους (peer reviewed):	Ναι
Κάτοχος πνευματικών δικαιωμάτων:	Copyright © 1996 Spandidos Publications Ltd. "Reproduced by permission of the Spandidos Publications Ltd"
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Ηλεκτρονική διεύθυνση περιοδικού (link) :	http://www.spandidos-publications.com/or/
Σημειώσεις:	Journal title: 2001 - , D N A Repair (1568-7864); Former titles: until 2001 Mutation Research - D N A Repair (Netherlands) (0921-8777); until 1988 Mutation Research - D N A Repair - Reports (Netherlands) (0167-8817)
ΙΒΦΧΒ: αρχειακή συλλογή:	Ινστιτούτο Βιολογικών Ερευνών και Βιοτεχνολογίας (ΙΒΕΒ) (έως 2012)
Εμφανίζεται στις συλλογές:	Ινστιτούτο Χημικής Βιολογίας - Επιστημονικό έργο