Εξειδίκευση τύπου :	Άρθρο σε επιστημονικό περιοδικό
Τίτλος:	Detection of human papilloma virus (HPV) and K-ras mutations in human lung carcinomas
Δημιουργός/Συγγραφέας:	Noutsou, A. Koffa, M. Ergazaki, M. Siafakas, N. M. [EL] Σπαντίδος, Δημήτριος Α.[EN] Spandidos, Demetrios A.
Εκδότης:	Demetrios A. Spandidos Ed. & Pub.
Ημερομηνία:	1996
Γλώσσα:	Αγγλικά
ISSN:	1019-6439
Περίληψη:	The purpose of our study was to assess the prevalence and prognostic significance of HPV infection as well as K-ras codon 12 point mutations in lung cancer. Patients diagnosed with lung carcinoma between 1988 and 1992 (N=99) were selected. HPV detection and typing was performed by PCR from paraffin-embedded tissues, while mutations in codon 12 of K-ras gene were detected using the restriction fragment length polymorphism (RFLP) analysis. The prevalence of HPV infection was 15%, while K-ras codon 12 point mutations were found in 18% of the specimens examined. In 50% of the HPV-positive cases, K-ras gene mutation coexisted. HPV 18 was the most frequent type. No correlation was found between K-ras mutation and HPV infection with sex, age and clinical outcome of the patient, or the histological type and the differentiation grade of the tumor. An association was found between K-ras codon 12 point mutations and the stage of the tumor, occurring more frequently at stage III (p=0.037). Infection with potentially oncogenic HPV types could co-operate with K-ras gene activation in the progression of the disease, since K-ras activation by point mutations seems to be a late event in lung carcinogenesis.
Τίτλος πηγής δημοσίευσης:	International Journal of Oncology
Τόμος/Κεφάλαιο:	8
Τεύχος:	6
Σελίδες:	1089-1093
Αξιολόγηση από ομότιμους (peer reviewed):	Ναι
Κάτοχος πνευματικών δικαιωμάτων:	© 1996 Spandidos Publications Ltd. "Reproduced by permission of the Spandidos Publications Ltd"
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Ηλεκτρονική διεύθυνση περιοδικού (link) :	http://www.spandidos-publications.com/ijo/
Σημειώσεις:	Journal title: 2001 - , D N A Repair (1568-7864); Former titles: until 2001 Mutation Research - D N A Repair (Netherlands) (0921-8777); until 1988 Mutation Research - D N A Repair - Reports (Netherlands) (0167-8817)
ΙΒΦΧΒ: αρχειακή συλλογή:	Ινστιτούτο Βιολογικών Ερευνών και Βιοτεχνολογίας (ΙΒΕΒ) (έως 2012)
Εμφανίζεται στις συλλογές:	Ινστιτούτο Χημικής Βιολογίας - Επιστημονικό έργο