Εξειδίκευση τύπου :	Άρθρο σε επιστημονικό περιοδικό
Τίτλος:	Altered binding of the AP-1 protein on a negative regulatory element of c-myc is correlated with the progression of the malignancy of the lung and may contribute to c-myc expression
Δημιουργός/Συγγραφέας:	Eliopoulos, A. G. [EL] Σπαντίδος, Δημήτριος Α.[EN] Spandidos, Demetrios A.
Εκδότης:	Demetrios A. Spandidos Ed. & Pub.
Ημερομηνία:	1994
Γλώσσα:	Αγγλικά
ISSN:	1021-335X
Περίληψη:	The binding activity of the AP-1 (FOS/JUN) complex to a negative regulatory element on the c-myc promoter was investigated in 7 tumour- versus normal lung specimens and it correlated with c-myc expression. AP-1 levels were found elevated in two samples representing stage I progression of the disease, while in three stage III tumour samples, the AP-1 binding activity was equal or slightly elevated compared with their normal adjacent tissue. Southern blot analysis revealed amplified c-myc in all three cases of stage III tumours. These results suggest that there is a negative correlation between FOS/JUN binding on c-myc promoter and the expression of c-myc during the progression of the disease, further supporting the fundamental role of AP-1 on c-myc regulation.
Τίτλος πηγής δημοσίευσης:	Oncology Reports
Τόμος/Κεφάλαιο:	1
Τεύχος:	1
Σελίδες:	139-143
Αξιολόγηση από ομότιμους (peer reviewed):	Ναι
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ΙΒΦΧΒ: αρχειακή συλλογή:	Ινστιτούτο Βιολογικών Ερευνών και Βιοτεχνολογίας (ΙΒΕΒ) (έως 2012)
Εμφανίζεται στις συλλογές:	Ινστιτούτο Χημικής Βιολογίας - Επιστημονικό έργο