Εξειδίκευση τύπου :	Άρθρο σε επιστημονικό περιοδικό
Τίτλος:	Estrogen receptor α and β in uterine fibroids: a basis for altered estrogen responsiveness
Δημιουργός/Συγγραφέας:	Bakas, Panagiotis Liapis, Angelos Vlahopoulos, Spiros Giner, Maria Logotheti, Stella Creatsas, Georgios Meligova, Aggeliki K.
Ημερομηνία:	2008-11
Γλώσσα:	Αγγλικά
DOI:	10.1016/j.fertnstert.2007.09.019
Περίληψη:	Objective: To investigate the relative expression and the DNA-binding status of estrogen receptors a and b in fibroids and normal myometrial tissue to explore the molecular basis of altered estrogen responsiveness of leiomyomas. Design: Biopsy samples from uterine fibroids and adjacent normal myometrial tissue at the follicular phase of the menstrual cycle. Setting: Aretaieio University Hospital and the National Hellenic Research Foundation, Athens, Greece. Patient(s): Thirty-five patients who underwent hysterectomy or myomectomy because of myoma symptoms. Intervention(s): None. Main Outcome Measure(s): Deoxyribonucleic acid–binding status of estrogen receptors a and b. Result(s): The level of messenger RNA expression of estrogen receptor a and b and the level of estrogen receptor as a whole are increased on average to a similar extent in leiomyomas compared with normal myometrium. Occasionally, however, estrogen receptor a is disproportionately increased in leiomyomas, and this appears to increase the amount of estrogen receptor a that binds to the estrogen-responsive element of estrogen target genes as homodimer rather than as heterodimer with estrogen receptor b. Conclusion(s): The estrogen receptor a–to–estrogen receptor b expression ratio rather than the individual expression levels determines the fraction of DNA-binding homodimers of estrogen receptor a and possibly the growth potential of myomas.
Τίτλος πηγής δημοσίευσης:	Fertility and Sterility
Τόμος/Κεφάλαιο:	90
Τεύχος:	5
Σελίδες:	1878-1885
Λέξεις-Κλειδιά:	Uterine myomas estrogen receptor alpha estrogen receptor beta myometrium fibroids
Κάτοχος πνευματικών δικαιωμάτων:	© 2008 American Society for Reproductive Medicine
Ηλεκτρονική διεύθυνση περιοδικού (link) :	http://www.sciencedirect.com/science/journal/00150282
ΙΒΦΧΒ: αρχειακή συλλογή:	Ινστιτούτο Βιολογικών Ερευνών και Βιοτεχνολογίας (ΙΒΕΒ) (έως 2012)
Εμφανίζεται στις συλλογές:	Ινστιτούτο Χημικής Βιολογίας - Επιστημονικό έργο