Εξειδίκευση τύπου :	Άρθρο σε επιστημονικό περιοδικό
Τίτλος:	p53 expression and mutations in squamous cell carcinoma of the head and neck: expression correlates with the patients' use of tocacco and alcohol
Δημιουργός/Συγγραφέας:	Field, John K. [EL] Ζουμπουρλής, Βασίλης[EN] Zoumpourlis, Vassilis [EL] Σπαντίδος, Δημήτριος Α.[EN] Spandidos, Demetrios A. Jones, Andrew S.
Ημερομηνία:	1994
Γλώσσα:	Αγγλικά
Περίληψη:	P53 expression was assessed in 93 head and neck squamous cell carcinoma patients using CM-1, DO-7, and DO-1 antibodies. Sixty eight percent was found to have positive nuclear staining. The frequency of p53 mutations were investigated in 13 patients using single-stranded conformational polymorphism (SSCP) analysis of DNA fragments that had been amplified by the polymerase chain reaction (PCR). P53 gene mutations were analyzed by SSCP in exons 4 to 7 of 13 patients, and nine were found to have mutations in exon 4; two of these patients also had a mutation in exon 5. In the group of 93 patients, p53 overexpression was found to correlate with the patients' history of heavy smoking (p <0.01). We also analyzed the drinking and smoking history of 71 of these patients by logistic regression analysis and found that heavy smoking correlates with p53 overexpression (p <0.05), but heavy drinking was not found to be significant. However when both smoking and drinking histories were assessed together, a correlation was found (p <0.05). Future work may indicate that specific p53 mutations are associated with patients who have a history of heavy drinking and smoking.
Τίτλος πηγής δημοσίευσης:	Cancer detection and prevention
Τόμος/Κεφάλαιο:	18
Τεύχος:	3
Σελίδες:	197-208
Θεματική Κατηγορία:	[EL] Εσωτερική ιατρική[EN] Internal medicine
Λέξεις-Κλειδιά:	p53 tumor suppressor gene expression mutations (SSCP) head and neck cancer smoking drinking survival Neoplasms. Tumors. Oncology
Κάτοχος πνευματικών δικαιωμάτων:	© 1994 by CRC Press, Inc.
ΙΒΦΧΒ: αρχειακή συλλογή:	Ινστιτούτο Βιολογικών Ερευνών και Βιοτεχνολογίας (ΙΒΕΒ) (έως 2012)
Εμφανίζεται στις συλλογές:	Ινστιτούτο Χημικής Βιολογίας - Επιστημονικό έργο