Εξειδίκευση τύπου :	Άρθρο σε επιστημονικό περιοδικό
Τίτλος:	Effect of histamine on the signal transduction of the AtoS–AtoC two component system and involvement in poly-(R)-3-hydroxybutyrate biosynthesis in Escherichia coli
Δημιουργός/Συγγραφέας:	[EL] Κυριακίδης, Δ.Α.[EN] Kyriakidis, D.A. Theodorou, M. C. Filippou, P. S. Kyriakidis, K. D. Tiligada, E.
Εκδότης:	Springer Wien
Ημερομηνία:	2008
Γλώσσα:	Αγγλικά
ISSN:	0939-4451
DOI:	10.1007/s00726-007-0635-8
Περίληψη:	AtoS-AtoC two-component system acts directly on the atoDAEB operon transcription to regulate the biosynthesis of short-chain poly-(R)-3- hydroxybutyrate. This study sought to investigate the effect of histamine and compound 48/80 on the regulation of AtoS-AtoC two-component system in Escherichia coli K-12 MA255 (speC -, speB -) and the isogenic E. coli strains BW25113 (atoSC +) and BW28878 (ΔatoSC) transformed with plasmids carrying related genes. Histamine or compound 48/80 induced or tended to reduce atoC transcription, respectively, while neither compound showed any effect on atoDAEB operon transcription. Moreover, histamine down-regulated poly-(R)-3-hydroxybutyrate biosynthesis, whereas compound 48/80 up-regulated its biosynthesis, maximal induction being obtained in the presence of multiple copies of AtoS-AtoC. Interestingly, co-administration of histamine counteracted this inductive effect of compound 48/80. The reported data provide the first evidence for a differential modulator role of histamine and compound 48/80 on the AtoS-AtoC two-component system signaling in potentially pathogenic bacteria, leading to a new perspective on their symbiotic behavior. © 2008 Springer-Verlag.
Τίτλος πηγής δημοσίευσης:	Amino Acids
Τόμος/Κεφάλαιο:	35
Τεύχος:	1
Σελίδες:	45-52
Κάτοχος πνευματικών δικαιωμάτων:	© Springer-Verlag 2008
Ηλεκτρονική διεύθυνση περιοδικού (link) :	http://www.springerlink.com/content/104405/
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