Εξειδίκευση τύπου :	Άρθρο σε επιστημονικό περιοδικό
Τίτλος:	Signal transduction and adaptive regulation through bacterial two-component systems: the Escherichia coli AtoSC paradigm
Δημιουργός/Συγγραφέας:	[EL] Κυριακίδης, Δ.Α.[EN] Kyriakidis, D.A. Tiligada, Ekaterini
Εκδότης:	Springer
Ημερομηνία:	2009-09
Γλώσσα:	Αγγλικά
ISSN:	0939-4451
DOI:	10.1007/s00726-009-0241-z
Περίληψη:	Adaptive signal transduction within microbial cells involves a multi-faceted regulated phosphotransfer mechanism that comprises structural rearrangements of sensor histidine kinases upon ligand-binding and phosphorylation- induced conformational changes in response regulators of versatile two-component systems (TCS), arisen early in bacterial evolution. In Escherichia coli, cross-talk between the AtoS histidine kinase and the AtoC response regulator, forming the AtoSC TCS, through His ? Asp phosphotransfer, activates AtoC directly to induce atoDAEB operon expression, thus modulating diverse fundamental cellular processes such as short-chain fatty acid catabolism, poly-(R)-3-hydroxybutyrate biosynthesis and chemotaxis. Among the inducers hitherto identified, acetoacetate is the classical activator. The AtoSC TCS functional modulation by polyamines, histamine and Ca2?, as well as the role of AtoC as transcriptional regulator, add new promising perspectives in the physiological significance and potential pharmacological exploitation of this TCS in cell proliferation, bacteria–host interactions, chemotaxis, and adaptation.
Τίτλος πηγής δημοσίευσης:	Amino Acids
Τόμος/Κεφάλαιο:	37
Τεύχος:	3
Σελίδες:	443-458
Θεματική Κατηγορία:	[EL] Χημεία (Γενικά)[EN] Chemistry (General) [EL] Βιολογία (Γενικά)[EN] Biology (General)
Λέξεις-Κλειδιά:	Antizyme AtoSC two-component system Escherichia coli Histamine Poly-(R)-3-hydroxybutyrate Polyamines
Κάτοχος πνευματικών δικαιωμάτων:	© Springer-Verlag 2009
Ηλεκτρονική διεύθυνση περιοδικού (link) :	http://www.springer.at/amino_acids
Εμφανίζεται στις συλλογές:	Άλλες δράσεις