Εξειδίκευση τύπου :	Άρθρο σε επιστημονικό περιοδικό
Τίτλος:	Proteasome activation as a novel antiaging strategy
Δημιουργός/Συγγραφέας:	[EL] Χονδρογιάννη, Νίκη[EN] Chondrogianni, Niki [EL] Γκόνος, Ευστάθιος[EN] Gonos, Efstathios S.
Εκδότης:	John Wiley & Sons Incorporated
Τόπος έκδοσης:	Hoboken
Ημερομηνία:	2008-10
Γλώσσα:	Αγγλικά
ISSN:	1521-6543
DOI:	10.1002/iub.99
Περίληψη:	Homeostasis is a key feature of cellular lifespan. Maintenance of cellular homeostasis influences the rate of aging and is determined by several factors, including efficient proteolysis of damaged proteins. Protein degradation is predominately catalyzed by the proteasome. Specifically, the proteasome is responsible for cell clearance of abnormal, denatured or in general damaged proteins as well as for the regulated degradation of short-lived proteins. As proteasome has an impaired function during aging, emphasis has been given recently in identifying ways of its activation. A number of studies have shown that the proteasome can be activated by genetic manipulations as well as by factors that affect its conformation and stability. Importantly the developed proteasome activated cell lines exhibit an extended lifespan. This review article discusses in details the various factors that are involved in proteasome biosynthesis and assembly and how they contribute to its activation. Finally as few natural compounds have been identified having proteasome activation properties, we discuss the advantages of this novel antiaging strategy.
Τίτλος πηγής δημοσίευσης:	Iubmb Life (formerly Biochemistry and Molecular Biology International) (no Longer Published by Taylor & Francis)
Τόμος/Κεφάλαιο:	60
Τεύχος:	10
Σελίδες:	651-655
Θεματική Κατηγορία:	[EL] Βιολογία (Γενικά)[EN] Biology (General)
Λέξεις-Κλειδιά:	aging homeostasis longevity proteasome protein degradation senescence
Αξιολόγηση από ομότιμους (peer reviewed):	Ναι
Κάτοχος πνευματικών δικαιωμάτων:	© 2008 IUBMB.
Όροι και προϋποθέσεις δικαιωμάτων:	This article appears in: Iubmb Life, v60, issue 10, p. 651-655, 2008 and can be found at the following URL on the website: https://iubmb.onlinelibrary.wiley.com/journal/15216551
Ηλεκτρονική διεύθυνση περιοδικού (link) :	https://iubmb.onlinelibrary.wiley.com/journal/15216551
Σημειώσεις:	Review
ΙΒΦΧΒ: αρχειακή συλλογή:	Ινστιτούτο Βιολογικών Ερευνών και Βιοτεχνολογίας (ΙΒΕΒ) (έως 2012)
Εμφανίζεται στις συλλογές:	Ινστιτούτο Χημικής Βιολογίας - Επιστημονικό έργο