Εξειδίκευση τύπου :	Άρθρο σε επιστημονικό περιοδικό
Τίτλος:	Carbon quantum dots/block copolymer ensembles for metal-ion sensing and bioimaging
Δημιουργός/Συγγραφέας:	Skaltsas T. Goulielmaki M. [EL] Πίντζας, Αλέξανδρος[EN] Pintzas, Alexander [EL] Πίσπας, Στέργιος[EN] Pispas, Stergios [EL] Ταγματάρχης, Νίκος[EN] Tagmatarchis, Nikos
Εκδότης:	Royal Society of Chemistry
Ημερομηνία:	2017
Γλώσσα:	Αγγλικά
ISSN:	2050-7518
DOI:	10.1039/c7tb01352c
Άλλο:	PubMed ID: 32264079
Περίληψη:	Fluorescent carbon quantum dots (CQDs) rich in amine moieties that can be easily protonated under acidic conditions were electrostatically interacted with diblock copolymer poly[sodium(carboxylate sulfamate) isoprene]-b-poly(ethylene oxide) (CSS-IEO-3) possessing negatively charged sulfamate and carboxylate species on the CSS part of the diblock copolymer. The so-formed CQDs/CSS-IEO-3 material was found to be stable in a neutral and high salinity environment, which is critical when aiming for biological applications. Moreover, the photoluminescence of CQDs within CQDs/CSS-IEO-3, with emission at 420 nm upon excitation at 320 nm, was unaffected by pH and salinity changes, denoting the absence of significant aggregation phenomena and highlighting the potential of CQDs/CSS-IEO-3 for bioimaging. The photoluminescence of CQDs/CSS-IEO-3 was employed to develop a selective and sensitive method for the facile detection of Fe3+, in the presence of other metal salts, with a detection limit of 8.37 μM. Furthermore, integration of bovine serum albumin (BSA) furnished the three-component CQDs/CSS-IEO-3·BSA nanoensemble, without causing cytotoxicity when subjected to RKO human colon adenocarcinoma cell line. Evidently, confocal fluorescence microscopy allowed the imaging of CQDs/CSS-IEO-3·BSA within living cells, and illustrated its application potential for bioimaging and drug delivery.
Τίτλος πηγής δημοσίευσης:	Journal of Materials Chemistry B
Τόμος/Κεφάλαιο:	5
Τεύχος:	27
Σελίδες:	5397-5402
Θεματική Κατηγορία:	[EL] Φυσική και θεωρητική χημεία[EN] Physical and theoretical chemistry
Αξιολόγηση από ομότιμους (peer reviewed):	Ναι
Κάτοχος πνευματικών δικαιωμάτων:	© 2017 The Royal Society of Chemistry.
Σημειώσεις:	Partial financial support from the General Secretariat for Research and Technology, Greece, through project "Advanced Materials and Devices" (MIS: 5002409) is acknowledged. We are indebted to Professor Hisanori Shinohara and his group at the Department of Chemistry, Nagoya University, Japan, for kind help with the HR-TEM imaging.
Εμφανίζεται στις συλλογές:	Ινστιτούτο Θεωρητικής και Φυσικής Χημείας (ΙΘΦΧ) - Επιστημονικό έργο