Εξειδίκευση τύπου :	Άρθρο σε επιστημονικό περιοδικό
Τίτλος:	Unravelling a p73-regulated network: The role of a novel p73-dependent target, MIR3158, in cancer cell migration and invasiveness
Δημιουργός/Συγγραφέας:	Galtsidis S. Logotheti S. Pavlopoulou A. Zampetidis C.P. Papachristopoulou G. Scorilas A. Vojtesek B. Gorgoulis V. [EL] Ζουμπουρλής, Βασίλης[EN] Zoumpourlis, Vassilis
Εκδότης:	Elsevier Ireland Ltd
Ημερομηνία:	2017
Γλώσσα:	Αγγλικά
ISSN:	0304-3835
DOI:	10.1016/j.canlet.2016.11.036
Άλλο:	PubMed ID: 27919789
Περίληψη:	The transcription factor p73 is homologous to the well-known tumor-suppressor p53. The p73-regulated networks are of significant clinical interest, because they may substitute for impaired p53-regulated networks which are commonly perturbed in cancer. Herein, we aimed to characterize a p73-regulated network that mediates cell migration and restores anti-oncogenic responses in p53-mutant cancer cells. In this study, we demonstrate that p73 regulates a network underlying cell migration, which consists of MIR34A/MIR3158/vimentin/β-catenin/lef1. The p73 isoforms transactivate the miRNA components (MIR34A/MIR3158) of this network, which in turn, downregulate their EMT-related mRNA co-targets (vimentin/β-catenin/lef1) to decrease cell-migration. Modulation of this network, by increasing the level of the novel p73-dependent target MIR3158, was found to induce anti-oncogenic/anti-invasive responses in p53-mutant cancer cells. Taken together, a p73-regulated, MIR3158-containing, network restores anti-invasive phenotypes in p53-mutant cancer cells; this property could be exploited towards the development of anticancer therapeutics.
Τίτλος πηγής δημοσίευσης:	Cancer Letters
Τόμος/Κεφάλαιο:	388
Σελίδες:	96-106
Θεματική Κατηγορία:	[EL] Βιολογία (Γενικά)[EN] Biology (General)
Λέξεις-Κλειδιά:	Anticancer targeting Epithelial–mesenchymal transition MIR3158 MIR34A p73
Αξιολόγηση από ομότιμους (peer reviewed):	Ναι
Κάτοχος πνευματικών δικαιωμάτων:	© 2016 Elsevier Ireland Ltd
Σημειώσεις:	SR 22893; LO1413; Grantová Agentura České Republiky, GA ČR: P206/12/G151; General Secretariat for Research and Technology, GSRT: 14TUR_p73. SG was supported by the General Secretariat of Research and Technology (project no. 14TUR_p73) [ESPA Czech-Greek bilateral cooperation (2012?2014); ESPA Greek-Turkey bilateral cooperation grant (2013?2015)]. SL was supported by IKY fellowships of excellence for postgraduate studies in Greece-Siemens program? [SR 22893]. BV was supported by the Czech Science Foundation (project no. P206/12/G151) and by the National sustainability program of Ministry of Education Youth, Education and Sports of the Czech Republic (project no. LO1413).
Εμφανίζεται στις συλλογές:	Ινστιτούτο Χημικής Βιολογίας - Επιστημονικό έργο