Εξειδίκευση τύπου :	Άρθρο σε επιστημονικό περιοδικό
Τίτλος:	A thermal analysis and physicochemical study on thermoresponsive chimeric liposomal nanosystems
Δημιουργός/Συγγραφέας:	Naziris, Nikolaos Skandalis, Athanasios Forys, Aleksander Trzebicka, Barbara [EL] Πίσπας, Στέργιος[EN] Pispas, Stergios Demetzos, Costas
Εκδότης:	Akadémiai Kiadó
Ημερομηνία:	2020
Γλώσσα:	Αγγλικά
ISSN:	1388-6150 1588-2926
DOI:	10.1007/s10973-019-09049-z
Περίληψη:	Thermoresponsive nanomaterials have led to a plethora of new applications in the fields of Nanobiotechnology, Biomedicine and Therapeutics. Since liposomal membranes are lyotropic liquid crystals, the development of thermoresponsive liposomes for drug delivery has been recognized as an attractive scientific field. Additionally, plenty of studies utilizing the temperature-dependent response of certain synthetic polymers are conducted, alone or in combination with liposomes. In the present study, we combined the liposomal and thermoresponsive polymer technologies, in order to create functional chimeric/mixed liposomal nanosystems with innovative properties. Initially, differential scanning calorimetry was applied on chimeric/mixed bilayers to evaluate the effect of polymeric guests on the thermotropic behavior of lipidic membranes. Thereafter, chimeric/mixed liposomes were built and their physicochemical properties, as well as their colloidal stability were measured and evaluated. The nature of the self-assembled structures and the lipidic membrane morphology were investigated through cryo-transmission electron microscopy, while their thermoresponsiveness and its consequences on the lipidic membrane properties were assessed, through a simple heating protocol. The presence of a new thermodynamic phase on the lipidic membrane acts as an agglomeration and aggregation inducer, affecting the whole colloidal chimeric/mixed nanosystem. This mechanism might be characterized as “phase functionality” and may be utilized for drug delivery purposes and also in other applications. Biophysics and thermodynamics are very important tools to study the self-assembly process, as well as the stability and bio-functionality of drug delivery systems.
Τίτλος πηγής δημοσίευσης:	Journal of Thermal Analysis and Calorimetry
Τόμος/Κεφάλαιο:	141
Τεύχος:	2
Σελίδες:	751–766
Θεματική Κατηγορία:	[EL] Φυσική και θεωρητική χημεία[EN] Physical and theoretical chemistry [EL] Φαρμακευτική χημεία[EN] Pharmaceutical chemistry [EL] Φαρμακευτική τεχνολογία[EN] Pharmaceutical technology [EL] Τεχνολογικές καινοτομίες. Αυτοματοποίηση[EN] Technological innovations. Automation
Λέξεις-Κλειδιά:	Chimeric liposomes Thermoresponsiveness Thermal analysis Light scattering Cryo-TEM Phase functionality
Κάτοχος πνευματικών δικαιωμάτων:	Copyright © 2020 Springer Nature Switzerland AG
Ηλεκτρονική διεύθυνση στον εκδότη (link):	https://link.springer.com/article/10.1007/s10973-019-09049-z
Ηλεκτρονική διεύθυνση περιοδικού (link) :	https://www.springer.com/journal/10973
Εμφανίζεται στις συλλογές:	Ινστιτούτο Θεωρητικής και Φυσικής Χημείας (ΙΘΦΧ) - Επιστημονικό έργο