Εξειδίκευση τύπου :	Άρθρο σε επιστημονικό περιοδικό
Τίτλος:	Urine Metabolomic Profile of Breast- versus Formula-Fed Neonates Using a Synbiotic-Enriched Formula
Δημιουργός/Συγγραφέας:	Falaina, Vasiliki Fotakis, Charalambos Boutsikou, Theodora Tsiaka, Thalia Moros, Georgios Ouzounis, Sotirios Andreou, Vasiliki Iliodromiti, Zoi Xanthos, Theodoros Vandenplas, Yvan Iacovidou, Nicoletta [EL] Ζουμπουλάκης, Παναγιώτης[EN] Zoumpoulakis, Panagiotis
Ημερομηνία:	2022-09-09
Γλώσσα:	Αγγλικά
ISSN:	1422-0067
DOI:	10.3390/ijms231810476
Άλλο:	36142388
Περίληψη:	The aim of this study was to compare the urine metabolic fingerprint of healthy neonates exclusively breastfed with that of neonates fed with a synbiotic-enriched formula (Rontamil® Complete 1) at four time points (the 3rd and 15th days of life and the 2nd and 3rd months). The determination of urine metabolic fingerprint was performed using NMR metabolomics. Multivariate data analyses were performed with SIMCA-P 15.0 software and R language. Non-distinct profiles for both groups (breastfeeding and synbiotic formula) for the two first time points (3rd and 15th days of life) were detected, whereas after the 2nd month of life, a discrimination trend was observed between the two groups, which was further confirmed at the 3rd month of life. A clear discrimination of the synbiotic formula samples was evident when comparing the metabolites taken in the first days of life (3rd day) with those taken in the 2nd and 3rd months of life. In both cases, OPLS-DA models explained more than 75% of the metabolic variance. Non-distinct metabolomic profiles were obtained between breastfed and synbiotic-formula-fed neonates up to the 15th day of life. Discrimination trends were observed only after the 2nd month of the study, which could be attributed to breastfeeding variations and the consequent dynamic profile of urine metabolites compared to the stable ingredients of the synbiotic formula.
Τίτλος πηγής δημοσίευσης:	International journal of molecular sciences
Τόμος/Κεφάλαιο:	23
Τεύχος:	18
Θεματική Κατηγορία:	[EL] Βιοχημεία[EN] Biochemistry [EL] Φασματοσκοπία[EN] Spectroscopy [EL] Νεογέννητα βρέφη[EN] Newborn infants [EL] Χημική Βιολογία[EN] Chemical Biology
Λέξεις-Κλειδιά:	Neonates Formula feeding Breastfeeding Urine metabolomics Synbiotics NMR spectroscopy Gut microbiota
Κάτοχος πνευματικών δικαιωμάτων:	© 2022 by the authors. Licensee MDPI, Basel, Switzerland.
Όροι και προϋποθέσεις δικαιωμάτων:	This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https:// creativecommons.org/licenses/by/ 4.0/).
Ηλεκτρονική διεύθυνση περιοδικού (link) :	https://www.mdpi.com/1422-0067/23/18/10476
Εμφανίζεται στις συλλογές:	Ινστιτούτο Χημικής Βιολογίας - Επιστημονικό έργο