Εξειδίκευση τύπου :	Άρθρο σε επιστημονικό περιοδικό
Τίτλος:	Bioenergetic Profiling in Glioblastoma Multiforme Patients with Different Clinical Outcomes
Δημιουργός/Συγγραφέας:	Bafiti, Vivi Ouzounis, Sotirios [EL] Σιάπη, Ελένη[EN] Siapi, Eleni Grypari, Ioanna Maria Theofanopoulos, Andreas Panagiotopoulos, Vasilios Zolota, Vasiliki Kardamakis, Dimitrios [EL] Κατσίλα, Θεοδώρα[EN] Katsila, Theodora
Ημερομηνία:	2023-02-28
Γλώσσα:	Αγγλικά
ISSN:	2218-1989
DOI:	10.3390/metabo13030362
Άλλο:	36984801
Περίληψη:	The accumulation of cell biomass is associated with dramatically increased bioenergetic and biosynthetic demand. Metabolic reprogramming, once thought as an epiphenomenon, currently relates to disease progression, also in response to extracellular fate-decisive signals. Glioblastoma multiforme patients often suffer misdiagnosis, short survival time, low quality of life, and poor disease management options. Today, tumor genetic testing and histological analysis guide diagnosis and treatment. We and others appreciate that metabolites complement translational biomarkers and molecular signatures in disease profiling and phenotyping. Herein, we coupled a mixed-methods content analysis to a mass spectrometry-based untargeted metabolomic analysis on plasma samples from glioblastoma multiforme patients to delineate the role of metabolic remodeling in biological plasticity and, hence, disease severity. Following data processing and analysis, we established a bioenergetic profile coordinated by the mitochondrial function and redox state, lipids, and energy substrates. Our findings show that epigenetic modulators are key players in glioblastoma multiforme cell metabolism, in particular when microRNAs are considered. We propose that biological plasticity in glioblastoma multiforme is a mechanism of adaptation and resistance to treatment which is eloquently revealed by bioenergetics.
Τίτλος πηγής δημοσίευσης:	Metabolites
Τόμος/Κεφάλαιο:	13
Τεύχος:	3
Θεματική Κατηγορία:	[EL] Νεοπλάσματα. Όγκοι. Ογκολογία (περ. Καρκίνος, κακινογόνες ουσίες)[EN] Neoplasms. Tumors. Oncology (Incl.cancer, carcinogens) [EL] Χημική Βιολογία[EN] Chemical Biology [EL] Βιοπληροφορική[EN] Bioinformatics [EL] Βιοχημεία[EN] Biochemistry [EL] Φαρμακευτική χημεία[EN] Pharmaceutical chemistry
Λέξεις-Κλειδιά:	Untargeted metabolomics Glioblastoma multiforme Translational biomarkers Bioenergetics Oncometabolism Metabolic reprogramming Epigenetic modulators Drug repurposing
EU Grant:	Entrepreneur-ship and Innovation, under the call RESEARCH–CREATE–INNOVATE
EU Grant identifier:	T2EDK-03153
Κάτοχος πνευματικών δικαιωμάτων:	© 2023 by the authors. Licensee MDPI, Basel, Switzerland.
Όροι και προϋποθέσεις δικαιωμάτων:	This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https:// creativecommons.org/licenses/by/ 4.0/).
Ηλεκτρονική διεύθυνση στον εκδότη (link):	https://www.mdpi.com/2218-1989/13/3/362
Εμφανίζεται στις συλλογές:	Ινστιτούτο Χημικής Βιολογίας - Επιστημονικό έργο