Εξειδίκευση τύπου :	Άρθρο σε επιστημονικό περιοδικό
Τίτλος:	Nutrient insufficiencies and deficiencies involved in the pathogenesis of bruxism (Review)
Δημιουργός/Συγγραφέας:	Pavlou, Ioannis A Spandidos, Demetrios A [EL] Ζουμπουρλής, Βασίλης[EN] Zoumpourlis, Vassilis Adamaki, Maria
Ημερομηνία:	2023-12
Γλώσσα:	Αγγλικά
ISSN:	1792-0981 1792-1015
DOI:	10.3892/etm.2023.12262
Άλλο:	37954114
Περίληψη:	Stress has been well-documented to have a significant role in the etiopathogenesis of bruxism. Activation of the hypothalamic-pituitary-adrenal axis (HPA) and subsequent release of corticosteroids lead to increased muscle activity. Neurological studies have demonstrated that chronic stress exposure induces neurodegeneration of important neuronal structures and destabilization of the mesocortical dopaminergic pathway. These disruptions impair the abilities to counteract the overactivity of the HPA axis and disinhibit involuntary muscle activity, while at the same time, there is activation of the amygdala. Recent evidence shows that overactivation of the amygdala under stressful stimuli causes rhythmic jaw muscle activity by over activating the mesencephalic and motor trigeminal nuclei. The present review aimed to discuss the negative effects of certain vitamin and mineral deficiencies, such as vitamin D, magnesium, and omega-3 fatty acids, on the central nervous system. It provides evidence on how such insufficiencies may increase stress sensitivity and neuromuscular excitability and thereby reduce the ability to effectively respond to the overactivation of the sympathetic nervous system, and also how stress can in turn lead to these insufficiencies. Finally, the positive effects of individualized supplementation are discussed in the context of diminishing anxiety and oxidative stress, neuroprotection and in the reversal of neurodegeneration, and also in alleviating/reducing neuromuscular symptoms.
Τίτλος πηγής δημοσίευσης:	Experimental and therapeutic medicine
Τόμος/Κεφάλαιο:	26
Τεύχος:	6
Θεματική Κατηγορία:	[EL] Νευροεπιστήμη. Βιολογική ψυχιατρική. Νευροψυχιατρική[EN] Neurosciences. Biological psychiatry. Neuropsychiatry [EL] Χημική Βιολογία[EN] Chemical Biology [EL] Βιοχημεία[EN] Biochemistry
Λέξεις-Κλειδιά:	Bruxism Iron Magnesium Neurodegeneration Omega-3 fatty acids Vitamin D
Κάτοχος πνευματικών δικαιωμάτων:	© 2023 Pavlou et al.
Όροι και προϋποθέσεις δικαιωμάτων:	This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivat ives 4.0 International (CC BY-NC-ND 4.0) License.
Εμφανίζεται στις συλλογές:	Ινστιτούτο Χημικής Βιολογίας - Επιστημονικό έργο