Εξειδίκευση τύπου :	Άρθρο σε επιστημονικό περιοδικό
Τίτλος:	Chitosan-Based Nanoparticles for Nucleic Acid Delivery: Technological Aspects, Applications, and Future Perspectives
Δημιουργός/Συγγραφέας:	Karayianni, Maria Sentoukas, Theodore Skandalis, Athanasios Pippa, Natassa [EL] Πίσπας, Στέργιος[EN] Pispas, Stergios
Ημερομηνία:	2023-06-29
Γλώσσα:	Αγγλικά
ISSN:	1999-4923
DOI:	10.3390/pharmaceutics15071849
Άλλο:	37514036
Περίληψη:	Chitosan is a naturally occurring polymer derived from the deacetylation of chitin, which is an abundant carbohydrate found mainly in the shells of various marine and terrestrial (micro)organisms. Chitosan has been extensively used to construct nanoparticles (NPs), which are biocompatible, biodegradable, non-toxic, easy to prepare, and can function as effective drug delivery systems. Moreover, chitosan NPs have been employed in gene and vaccine delivery, as well as advanced cancer therapy, and they can also serve as new therapeutic tools against viral infections. In this review, we summarize the most recent developments in the field of chitosan-based NPs intended as nucleic acid delivery vehicles and gene therapy vectors. Special attention is given to the technological aspects of chitosan complexes for nucleic acid delivery.
Τίτλος πηγής δημοσίευσης:	Pharmaceutics
Τόμος/Κεφάλαιο:	15
Τεύχος:	7
Θεματική Κατηγορία:	[EL] Χημεία[EN] Chemistry [EL] Βιοχημεία[EN] Biochemistry
Λέξεις-Κλειδιά:	DNA RNA chitosan gene therapy nanoparticles nucleic acid delivery polyelectrolyte complexation polyplex
Ηλεκτρονική διεύθυνση στον εκδότη (link):	https://www.mdpi.com/1999-4923/15/7/1849
Εμφανίζεται στις συλλογές:	Ινστιτούτο Θεωρητικής και Φυσικής Χημείας (ΙΘΦΧ) - Επιστημονικό έργο