Εξειδίκευση τύπου :	Άρθρο σε επιστημονικό περιοδικό
Τίτλος:	Multiomic Signatures of Traffic-Related Air Pollution in London Reveal Potential Short-Term Perturbations in Gut Microbiome-Related Pathways
Δημιουργός/Συγγραφέας:	Cheng, Sibo Lucas Hedges, Michael Keski-Rahkonen, Pekka Chatziioannou, Anastasia Chrysovalantou Scalbert, Augustin Chung, Kian Fan Sinharay, Rudy Green, David C de Kok, Theo M C M Vlaanderen, Jelle [EL] Κυρτόπουλος, Σωτήριος Α.[EN] Kyrtopoulos, Soterios A. Kelly, Frank Portengen, Lützen Vineis, Paolo Vermeulen, Roel C H Chadeau-Hyam, Marc Dagnino, Sonia
Ημερομηνία:	2024-05-21
Γλώσσα:	Αγγλικά
ISSN:	0013-936X 1520-5851
DOI:	10.1021/acs.est.3c09148
Άλλο:	38728551
Περίληψη:	This randomized crossover study investigated the metabolic and mRNA alterations associated with exposure to high and low traffic-related air pollution (TRAP) in 50 participants who were either healthy or were diagnosed with chronic pulmonary obstructive disease (COPD) or ischemic heart disease (IHD). For the first time, this study combined transcriptomics and serum metabolomics measured in the same participants over multiple time points (2 h before, and 2 and 24 h after exposure) and over two contrasted exposure regimes to identify potential multiomic modifications linked to TRAP exposure. With a multivariate normal model, we identified 78 metabolic features and 53 mRNA features associated with at least one TRAP exposure. Nitrogen dioxide (NO2) emerged as the dominant pollutant, with 67 unique associated metabolomic features. Pathway analysis and annotation of metabolic features consistently indicated perturbations in the tryptophan metabolism associated with NO2 exposure, particularly in the gut-microbiome-associated indole pathway. Conditional multiomics networks revealed complex and intricate mechanisms associated with TRAP exposure, with some effects persisting 24 h after exposure. Our findings indicate that exposure to TRAP can alter important physiological mechanisms even after a short-term exposure of a 2 h walk. We describe for the first time a potential link between NO2 exposure and perturbation of the microbiome-related pathways.
Τίτλος πηγής δημοσίευσης:	Environmental science & technology
Τόμος/Κεφάλαιο:	58
Τεύχος:	20
Θεματική Κατηγορία:	[EL] Περιβαλλοντική υγεία[EN] Environmental health [EL] Βιοχημεία[EN] Biochemistry [EL] Μοριακή Βιολογία[EN] Molecular Biology
Λέξεις-Κλειδιά:	cluster chemistry mathematical methods metabolism metabolomics particulate matter air pollution exposome multiomics tryptophan
Κάτοχος πνευματικών δικαιωμάτων:	© 2024 The Authors. Published by American Chemical Society
Όροι και προϋποθέσεις δικαιωμάτων:	This publication is licensed under CC-BY 4.0 .
Ηλεκτρονική διεύθυνση στον εκδότη (link):	https://doi.org/10.1021/acs.est.3c09148
Εμφανίζεται στις συλλογές:	Ινστιτούτο Χημικής Βιολογίας - Επιστημονικό έργο