Εξειδίκευση τύπου :	Άρθρο σε επιστημονικό περιοδικό
Τίτλος:	A multi-omics approach to investigate the inflammatory response to life course socioeconomic position
Δημιουργός/Συγγραφέας:	Castagné, Raphaële Kelly-Irving, Michelle Krogh, Vittorio Palli, Domenico Panico, Salvatore Sacerdote, Carlotta Tumino, Rosario Hebels, Dennie Gaj Kleinjans, Jos Cs de Kok, Theo McM [EL] Γεωργιάδης, Παναγιώτης[EN] Georgiadis, Panagiotis [EL] Κυρτόπουλος, Σωτήριος Α.[EN] Kyrtopoulos, Soterios A. Vermeulen, Roel Stringhini, Silvia Vineis, Paolo Chadeau-Hyam, Marc Delpierre, Cyrille
Ημερομηνία:	2020-08
Γλώσσα:	Αγγλικά
ISSN:	1750-1911 1750-192X
DOI:	10.2217/epi-2019-0261
Άλλο:	32875816
Περίληψη:	Aim: Inflammation represents a potential pathway through which socioeconomic position (SEP) is biologically embedded. Materials & methods: We analyzed inflammatory biomarkers in response to life course SEP by integrating multi-omics DNA-methylation, gene expression and protein level in 178 European Prospective Investigation into Cancer and Nutrition-Italy participants. Results & conclusion: We identified 61 potential cis acting CpG loci whose methylation levels were associated with gene expression at a Bonferroni correction. We examined the relationships between life course SEP and these 61 cis-acting regulatory methylation sites individually and jointly using several scores. Less-advantaged SEP participants exhibit, later in life, a lower inflammatory methylome score, suggesting an overall increased expression of the corresponding inflammatory genes or proteins, supporting the hypothesis that SEP impacts adult physiology through inflammation.
Τίτλος πηγής δημοσίευσης:	Epigenomics
Τόμος/Κεφάλαιο:	12
Τεύχος:	15
Σελίδες:	1287-1302
Θεματική Κατηγορία:	[EL] Γενετική[EN] Genetics [EL] Βιολογία (Γενικά)[EN] Biology (General) [EL] Ιατρική[EN] Medicine
Λέξεις-Κλειδιά:	DNA methylation Gene expression Inflammation Life course epidemiology Protein Socioeconomic position Adult CpG Islands DNA Methylation Female Humans Inflammation Italy Male Middle Aged Epigenome Social Class Social Determinants of Health
Κάτοχος πνευματικών δικαιωμάτων:	Copyright © 2020 Raphaele Castagn
Ηλεκτρονική διεύθυνση με ανοικτή πρόσβαση (link):	https://www.futuremedicine.com/doi/10.2217/epi-2019-0261
Ηλεκτρονική διεύθυνση στον εκδότη (link):	https://www.futuremedicine.com/journal/epi
Εμφανίζεται στις συλλογές:	Ινστιτούτο Χημικής Βιολογίας - Επιστημονικό έργο